Expression of Type I Hair Keratins in Follicular Tumors

May 2001 in “ British Journal of Dermatology ”

B. Cribier, Bernard Peltre, Lutz Langbein, Hermelita Winter, J. Schweizer, E Grosshans

TLDR Pilomatrixomas likely originate from the hair matrix due to changes in hair keratin expression.

The study on pilomatrixomas, a type of follicular tumor, revealed that as these tumors mature into large areas of shadow cells, there was a gradual loss of differentiation-specific hair keratins. This change in hair keratin expression patterns supported the hypothesis that pilomatrixomas originated from the hair matrix, as evidenced by the complex hair keratin expression observed in these tumors.

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research Expression of Type I Hair Keratins in Follicular Tumors

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Pilomatrixomas likely originate from the hair matrix due to changes in hair keratin expression.

research Keratin 19: Predicted Amino Acid Sequence and Broad Tissue Distribution Suggest It Evolved from Keratinocyte Keratins

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Expression of Type I Hair Keratins in Follicular Tumors

Research cited in this study

research Immunohistochemical Localization of Cytokeratins and Involucrin in Calcifying Epithelioma: Comparative Studies with Normal Skin

research Characterization of a 300 Kbp Region of Human DNA Containing the Type II Hair Keratin Gene Domain

research Multiple Roles for Activated LEF/TCF Transcription Complexes During Hair Follicle Development and Differentiation

research Identification of Novel Mutations in Basic Hair Keratins hHb1 and hHb6 in Monilethrix: Implications for Protein Structure and Clinical Phenotype

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research WNT Signaling in the Control of Hair Growth and Structure

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research Expression of Type I Hair Keratins in Follicular Tumors

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