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GlossaryPilomatricoma

benign skin tumor originating from hair follicle matrix cells

Pilomatricoma, also known as Calcifying Epithelioma of Malherbe or Pilomatrixoma, is a benign skin tumor that originates from hair follicle matrix cells. It typically presents as a firm, painless lump under the skin, often on the face, neck, or arms, and can sometimes become calcified. While it is generally non-cancerous, surgical removal is usually recommended to prevent potential complications.

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research Expression of Type I Hair Keratins in Follicular Tumors

26 citations , May 2001 in “British Journal of Dermatology”

Pilomatrixomas likely originate from the hair matrix due to changes in hair keratin expression.

research Cutaneous Neoplasms in Myotonic Dystrophy Type 1

10 citations , January 2016 in “Dermatology”

People with myotonic dystrophy type 1 tend to develop basal cell carcinoma at a younger age but not more frequently than others.

research A Histochemical Test for Citrulline: Adaptation of the Carbamido Diacetyl Reaction to Histologic Sections with Positive Results in Pilomatrixomas (Calcifying Epitheliomas)

20 citations , February 1968 in “Journal of Histochemistry & Cytochemistry”

A new test more accurately detects citrulline in hair follicles and pilomatrixomas.

research Diagnostic Value of High-Frequency Ultrasound in Evaluation of Subcutaneous Lesions

8 citations , September 2023 in “Skin Research and Technology”

High-frequency ultrasound improves diagnosis accuracy for most subcutaneous lesions.

research Proliferating Giant Pilomatrixoma: A Case Report

May 2025 in “Cureus”

Recognizing and fully removing giant pilomatrixomas is crucial to prevent them from becoming cancerous.

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