TLDR Mutations in specific keratin genes cause improper hair structure in mice due to faulty keratin protein assembly.
The study identified mutations in the helix termination motif of type I IRS keratin genes Krt25 and Krt27 in mice with hair coat mutations, which impaired the assembly of keratin intermediate filaments and led to abnormal hair and vibrissae phenotypes. Specifically, Re and M100573 had nonsynonymous base substitutions in Krt25, while Rewc had a deletion in Krt27. These mutations disrupted the keratin filament network, highlighting the essential role of the helix termination motif in keratin filament assembly and the formation of hair follicles, providing insights into hair growth and alopecia.
70 citations,
December 2004 in “Differentiation” The study identified and characterized new keratin genes linked to hair follicles and epithelial tissues.
36 citations,
January 2004 in “European journal of cell biology” Without keratin 10, there's more growth and development of oil-producing skin cells.
86 citations,
May 2002 in “Journal of Investigative Dermatology” A new keratin, hK6irs1, is found in all layers of the hair follicle's inner root sheath.
86 citations,
December 2001 in “Experimental dermatology” Mutant mice help researchers understand hair growth and related genetic factors.
3 citations,
January 2023 in “Science advances” The enzymes Tet2 and Tet3 are important for skin cell development and hair growth.
17 citations,
May 2012 in “Journal of biological chemistry/The Journal of biological chemistry” Hairless protein affects hair follicle structure by regulating the Dlx3 gene.
40 citations,
June 2013 in “Scientific Reports” A gene variant in KRT71 causes the curly fur in Selkirk Rex cats.
14 citations,
June 2022 in “BMC genomics” Key genes crucial for sheep hair follicle development were identified, aiding fine wool breeding and human hair loss research.
13 citations,
April 2018 in “Scientific Reports” The genes KRT25 and SP6 affect curly hair in horses, with KRT25 also causing hair loss. If both genes are mutated, the horse gets curly hair and hair loss. KRT25 can hide the effect of SP6.
