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research Mutations in the Helix Termination Motif of Mouse Type I IRS Keratin Genes Impair the Assembly of Keratin Intermediate Filament

27 citations , November 2007 in “Genomics”

Mutations in specific keratin genes cause improper hair structure in mice due to faulty keratin protein assembly.

research Structural Stability of Wild Type and Mutated Alpha-Keratin Fragments: Molecular Dynamics and Free Energy Calculations

40 citations , September 2004 in “Biomacromolecules”

The Glu413Lys mutation in keratin affects hair stability, while Glu413Asp does not.

research Monilethrix: A Novel Mutation (Glu402Lys) in the Helix Termination Motif and the First Causative Mutation (Asn114Asp) in the Helix Initiation Motif of the Type II Hair Keratin hHb6

29 citations , August 1999 in “Journal of Investigative Dermatology”

New mutations in hair keratin genes cause the rare hair disorder monilethrix.

research Monilethrix: Mutational Hotspot in the Helix Termination Motif of the Human Hair Basic Keratin 6

32 citations , January 2000 in “Human Heredity”

Monilethrix severity varies and may be influenced by other genetic or environmental factors.

research A Missense Mutation Within the Helix Termination Motif of KRT25 Causes Autosomal Dominant Woolly Hair/Hypotrichosis

33 citations , September 2017 in “Journal of Investigative Dermatology”

A mutation in the KRT25 gene causes woolly hair and hair loss.

View more "helix termination motif" in research →

Community Join

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community Minoxidil inhibits lysyl hydroxylase which is needed to produce collagen. If I take 2,5...5 mg of minoxidil every day can I cause my skin to age prematurely?

in Minoxidil 32 upvotes 1 year ago

Oral minoxidil is effective for hair loss and unlikely to significantly affect collagen synthesis, making it a safe option without causing premature skin aging. Users report positive hair regrowth without noticeable skin aging.

community Why is nobody studying the difference between donor and balding hair?

in Chat 89 upvotes 1 year ago

The conversation discusses why the difference between donor and balding hair isn't studied more to find a cure for hair loss. Treatments mentioned include Minoxidil, finasteride, and RU58841.

community Took the plunge last night and I finally met myself! 24 y.o Female pattern hair loss. Hated living with the insecurity for years and finally did it! Posting my whole face cause I’m so fckn happy y’all! Hope to inspire anyone who needs it. Love.

in Shaved/buzzed 1358 upvotes 4 years ago

User "kingkaurr" shaved head due to female pattern hair loss and feels happy and confident. Others compliment her look and discuss how head shaving is perceived differently for men and women.