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GlossaryKeratin 2 (KRT2)

protein providing structural strength to skin, hair, and nails

Keratin 2 (KRT2) is a type of protein found in the outer layer of the skin, hair, and nails. It plays a crucial role in providing structural strength and resilience to these tissues, helping to protect them from damage and wear. Mutations in the KRT2 gene can lead to skin disorders such as ichthyosis bullosa of Siemens, which is characterized by blistering and scaling of the skin.

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research Transcriptome Sequencing Reveals Key Genes Associated With Hair Follicle Development in Qianhua Mutton Merino

December 2025 in “Frontiers in Veterinary Science”

Key genes like KRT27 and IGF-2 are crucial for hair follicle development in Qianhua Mutton Merino sheep.

research Expression Patterns of Keratin Intermediate Filament and Keratin Associated Protein Genes in Wool Follicles

95 citations , March 2009 in “Differentiation”

Gene expression in wool follicles changes with growth cycles, offering insights into wool and human hair growth.

research Mutations in the Helix Termination Motif of Mouse Type I IRS Keratin Genes Impair the Assembly of Keratin Intermediate Filament

27 citations , November 2007 in “Genomics”

Mutations in specific keratin genes cause improper hair structure in mice due to faulty keratin protein assembly.

research Hairless Plays a Role in Formation of Inner Root Sheath via Regulation of Dlx3 Gene

17 citations , March 2012 in “Journal of biological chemistry/The Journal of biological chemistry”

Hairless protein affects hair follicle structure by regulating the Dlx3 gene.

research Screening and Expression of Keratin EST in Xinji Fine Wool Sheep

1 citations , January 2015 in “China Animal Husbandry & Veterinary Medicine”

Four keratin genes are crucial for hair growth in Xinji fine wool sheep.

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