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GlossaryKeratin 25 (KRT25)

protein crucial for hair fiber strength and integrity

Keratin 25 (KRT25) is a type of protein found in the hair and skin, specifically classified as a type I keratin. It plays a crucial role in the structural integrity and strength of hair fibers. Mutations or deficiencies in KRT25 can lead to hair disorders and contribute to conditions like alopecia.

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research An Epistatic Effect of KRT25 on SP6 Is Involved in Curly Coat in Horses

13 citations, April 2018 in “Scientific Reports”

The genes KRT25 and SP6 affect curly hair in horses, with KRT25 also causing hair loss. If both genes are mutated, the horse gets curly hair and hair loss. KRT25 can hide the effect of SP6.

research Hair Greying Is Associated With Active Hair Growth

36 citations, September 2011 in “British Journal of Dermatology”

White hair grows thicker and faster than black hair due to higher activity of growth-related genes and proteins.

research Mutations in the Helix Termination Motif of Mouse Type I IRS Keratin Genes Impair the Assembly of Keratin Intermediate Filament

27 citations, November 2007 in “Genomics”

Mutations in specific keratin genes cause improper hair structure in mice due to faulty keratin protein assembly.

research Hairless Plays a Role in Formation of Inner Root Sheath via Regulation of Dlx3 Gene

17 citations, May 2012 in “Journal of biological chemistry/The Journal of biological chemistry”

Hairless protein affects hair follicle structure by regulating the Dlx3 gene.

research Isolated Autosomal Recessive Woolly Hair/Hypotrichosis: Genetics, Pathogenesis, and Therapies

9 citations, May 2021 in “JEADV. Journal of the European Academy of Dermatology and Venereology/Journal of the European Academy of Dermatology and Venereology”

Topical minoxidil may help treat a rare genetic hair condition with no fully effective treatments yet.

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