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GlossaryKeratin 25 (KRT25)

protein crucial for hair fiber strength and integrity

Keratin 25 (KRT25) is a type of protein found in the hair and skin, specifically classified as a type I keratin. It plays a crucial role in the structural integrity and strength of hair fibers. Mutations or deficiencies in KRT25 can lead to hair disorders and contribute to conditions like alopecia.

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research A Missense Mutation Within the Helix Termination Motif of KRT25 Causes Autosomal Dominant Woolly Hair/Hypotrichosis

33 citations , September 2017 in “Journal of Investigative Dermatology”

A mutation in the KRT25 gene causes woolly hair and hair loss.

research An Epistatic Effect of KRT25 on SP6 Is Involved in Curly Coat in Horses

13 citations , April 2018 in “Scientific Reports”

The genes KRT25 and SP6 affect curly hair in horses, with KRT25 also causing hair loss. If both genes are mutated, the horse gets curly hair and hair loss. KRT25 can hide the effect of SP6.

research Autosomal Recessive Hypotrichosis With Woolly Hair Caused By A Mutation In The Keratin 25 Gene Expressed In Hair Follicles

50 citations , February 2016 in “Journal of Investigative Dermatology”

A mutation in the KRT25 gene causes a rare hair disorder with thin, woolly hair.

research A Homozygous Missense Variant in Type I Keratin KRT25 Causes Autosomal Recessive Woolly Hair

29 citations , July 2015 in “Journal of Medical Genetics”

A genetic variant in the KRT25 gene causes tightly curled hair.

research Discrimination of Dysplastic Nevi from Common Melanocytic Nevi by Cellular and Molecular Criteria

41 citations , July 2016 in “Journal of Investigative Dermatology”

Dysplastic nevi have unique gene expressions, making them distinct from common melanocytic nevi.

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