A Novel Type II Cytokeratin, mK6irs, Is Expressed in the Huxley and Henle Layers of the Mouse Inner Root Sheath

March 2001 in “ Journal of Investigative Dermatology ”

Noriaki Aoki, S. Sawada, Yutaka Shimomura, Tomotaka Tsujimoto, Kaoru Ito, Masaaki Ito, Michael A. Rogers, Jürgen Schweizer

cytokeratin mK6irs inner root sheath anagen phase hair growth hair cycle hair follicle biology hereditary hair diseases cicatricial alopecia monilethrix hair follicle hair loss hair structure

Studysummary This study identified a new cytokeratin, mK6irs, specifically expressed in the inner root sheath of mouse hair follicles, distinguishing it as a member of the type II cytokeratin family. Our plain-language summary of this paper — not a Tressless recommendation.

The study identified a novel type II cytokeratin, mK6irs, specifically expressed in the Huxley and Henle layers of the mouse inner root sheath (IRS) during the anagen phase of hair growth. This 57 kDa protein showed homology with other cytokeratins and was confirmed through various analyses to be present only during specific phases of the hair cycle. The research suggested that mK6irs played a role in the differentiation and structure of the IRS, contributing to the understanding of hair follicle biology. Additionally, the study proposed that mK6irs could be important for understanding hereditary hair diseases, as mutations in keratins are linked to conditions like cicatricial alopecia and monilethrix.

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