Isolation and Characterization of Mouse High-Glycine/Tyrosine Proteins

November 1997 in “ Journal of Biological Chemistry ”

Noriaki Aoki, Kaoru Ito, Masaaki Ito

TLDR Mouse high-glycine/tyrosine proteins have distinct patterns in hair follicles, peaking at specific hair cycle days.

The study isolated and characterized mouse high-glycine/tyrosine proteins (HGTps) from a cDNA library, identifying six members categorized into type I and type II proteins, including a novel type II.4 protein. These proteins showed distinct expression patterns linked to the hair cycle, peaking during anagen phases and localized to cortical cells of hair follicles. The research highlighted evolutionary conservation and structural features of HGTps, suggesting their role in hair differentiation and strengthening, particularly in the first hair cycle. This work provided foundational insights into the genetic and protein composition of mouse hair, contributing to the understanding of hair protein structure and function.

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research Isolation and Characterization of Genomic Clones of Human Sequences Presumably Coding for Hair Cysteine-Rich Proteins

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research Characterization of a Gene Encoding a Cysteine-Rich Keratin Associated Protein Synthesized Late in Rabbit Hair Follicle Differentiation

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Cells Within the Bulge Region of Mouse Hair Follicle Transiently Proliferate During Early Anagen: Heterogeneity and Functional Differences of Various Hair Cycles

research Cells Within the Bulge Region of Mouse Hair Follicle Transiently Proliferate During Early Anagen: Heterogeneity and Functional Differences of Various Hair Cycles

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Mouse hair follicle cells briefly grow during the early hair growth phase, showing that these cells are important for starting the hair cycle.

research Sequence, expression, and evolutionary conservation of a gene encoding a glycine/tyrosine-rich keratin-associated protein of hair.

76 citations , February 1993 in “Journal of Biological Chemistry”

KAP6 genes are conserved across species and active in hair follicles.

Isolation and Characterization of Mouse High-Glycine/Tyrosine Proteins

Research cited in this study

research Isolation and Characterization of Genomic Clones of Human Sequences Presumably Coding for Hair Cysteine-Rich Proteins

research Characterization of a Gene Encoding a Cysteine-Rich Keratin Associated Protein Synthesized Late in Rabbit Hair Follicle Differentiation

research Cells Within the Bulge Region of Mouse Hair Follicle Transiently Proliferate During Early Anagen: Heterogeneity and Functional Differences of Various Hair Cycles

research Sequence, expression, and evolutionary conservation of a gene encoding a glycine/tyrosine-rich keratin-associated protein of hair.

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