Isolation and Characterization of Genomic Clones of Human Sequences Presumably Coding for Hair Cysteine-Rich Proteins

January 1997 in “ Journal of Dermatological Science ”

Nathalie Emonet, Jean‐Jacques Michaille, Danielle Dhouailly

TLDR A new protein linked to hair strength was identified, aiding in understanding brittle hair conditions.

The study identified a human sequence potentially coding for a new ultra-high sulphur protein (hUHSp21) and isolated and characterized four genomic clones containing six related sequences. These findings suggested that genes encoding keratin-associated proteins might be evolutionarily related. The research provided molecular tools for studying hair differentiation and understanding the molecular basis of human trichothiodystrophy, a condition characterized by sulfur-deficient brittle hair.

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Research cited in this study

11 / 11 results

research Differential Expression of Genes Encoding a Cysteine-Rich Keratin Family in the Hair Cuticle

35 citations , September 1994 in “Journal of Investigative Dermatology”

research Isolation and Characterization of a Novel Hair Follicle-Specific Gene, Hacl-1

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research Organization and Expression of Hair Follicle Genes

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Hair growth is controlled by specific gene clusters and proteins, and cysteine affects hair gene expression in sheep.

research Analysis of the sheep trichohyalin gene: potential structural and calcium-binding roles of trichohyalin in the hair follicle.

72 citations , May 1993 in “The Journal of Cell Biology”

Trichohyalin in sheep hair follicles may help with structure and calcium binding.

research Sequence, expression, and evolutionary conservation of a gene encoding a glycine/tyrosine-rich keratin-associated protein of hair.

76 citations , February 1993 in “Journal of Biological Chemistry”

KAP6 genes are conserved across species and active in hair follicles.

research Regulation of Keratin Gene Expression in Hair Follicle Differentiation^a

98 citations , December 1991 in “Annals of the New York Academy of Sciences”

Keratin gene regulation is similar across mammals, affecting hair follicle differentiation.

research An ultrahigh-sulphur keratin gene of the human hair cuticle is located at 11q13 and cross-hybridizes with sequences at 11p15

15 citations , January 1991 in “Mammalian Genome”

research Structure and biochemistry of mammalian hard keratin

252 citations , January 1991 in “Electron Microscopy Reviews”

research Structure and Expression of Genes for a Class of Cysteine-Rich Proteins of the Cuticle Layers of Differentiating Wool and Hair Follicles

67 citations , December 1990 in “The journal of cell biology/The Journal of cell biology”

Researchers found genes for cysteine-rich proteins that form the protective layer of hair in humans and sheep.

research Serine-rich ultra high sulfur protein gene expression in murine hair and skin during the hair cycle.

26 citations , December 1990 in “Journal of Biological Chemistry”

Two specific genes are more active during hair growth in mice.

research An Ultra-high Sulfur Keratin Gene is Expressed Specifically During Hair Growth

38 citations , February 1989 in “Journal of Investigative Dermatology”

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