Isolation and Characterization of Genomic Clones of Human Sequences Presumably Coding for Hair Cysteine-Rich Proteins

    January 1997 in “ Journal of Dermatological Science ”
    Nathalie Emonet, Jean‐Jacques Michaille, Danielle Dhouailly
    TLDR A new protein linked to hair strength was identified, aiding in understanding brittle hair conditions.
    The study identified a human sequence potentially coding for a new ultra-high sulphur protein (hUHSp21) and isolated and characterized four genomic clones containing six related sequences. These findings suggested that genes encoding keratin-associated proteins might be evolutionarily related. The research provided molecular tools for studying hair differentiation and understanding the molecular basis of human trichothiodystrophy, a condition characterized by sulfur-deficient brittle hair.
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