Serine-Rich Ultra High Sulfur Protein Gene Expression in Murine Hair and Skin During the Hair Cycle

December 1990 in “ Journal of Biological Chemistry ”

Linda S. Wood, Mark Carter Mills, Nicole T. Hatzenbuhler, Gabriel Vögeli

serine-rich ultra high sulfur protein gUHS-SER-1 gUHS-SER-2 cysteine serine hair cycle mRNA medulla inner root sheath epidermis

TLDR Two specific genes are more active during hair growth in mice.

The study investigated the expression of serine-rich ultra high sulfur protein genes in mice during the hair cycle. Two genes, gUHS-SER-1 and gUHS-SER-2, were identified, encoding proteins with high cysteine and serine content. These genes showed 73% similarity and contained several 10-amino acid repeats. The research found that mRNA levels for these genes were elevated during active hair growth phases and low during resting phases. In situ hybridization revealed that mRNA was present in the medulla, inner root sheath of forming hair, and upper layers of the epidermis during active hair growth phases.

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Research cited in this study

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research Hair-Specific Expression of Chloramphenicol Acetyltransferase in Transgenic Mice Under the Control of an Ultra-High-Sulfur Keratin Promoter

33 citations , September 1990 in “Proceedings of the National Academy of Sciences”

The study showed that a specific DNA sequence can control gene expression in hair growth areas of mice.

research Expression of Keratin K14 in the Epidermis and Hair Follicle: Insights Into Complex Programs of Differentiation

198 citations , November 1989 in “The Journal of Cell Biology”

Keratin K14 expression varies between hair follicles and epidermis, affecting cell differentiation.

research An Ultra-High Sulfur Keratin Gene Is Expressed Specifically During Hair Growth

38 citations , February 1989 in “Journal of Investigative Dermatology”

research Cloning And Characterization Of A Mouse Type I Hair Keratin cDNA

41 citations , December 1988 in “Journal of Investigative Dermatology”

research The Complement of Native Alpha-Keratin Polypeptides of Hair-Forming Cells: A Subset of Eight Polypeptides That Differ from Epithelial Cytokeratins

198 citations , October 1986 in “Differentiation”

research Trichohyalin, an Intermediate Filament-Associated Protein of the Hair Follicle

116 citations , April 1986 in “The journal of cell biology/The Journal of cell biology”

Trichohyalin is a protein in hair follicles that helps form hair filaments.

research Growth of the Hair

521 citations , January 1954 in “Physiological Reviews”

Hair growth is cyclic and influenced mainly by local factors.

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