Special Biochemical Features of the Hair Follicle

    January 1988
    G.E. Rogers, Elizabeth S. Kuczek, Philip J. MacKinnon, Richard B. Presland, Michael Fietz
    TLDR Hair follicles have unique proteins that vary by species and are influenced by nutrition.
    The document discussed unique keratin proteins found in hair and wool, specifically high-glycine/tyrosine (HGT) proteins, ultra-high-sulphur (UHS) proteins, and trichohyalin protein. These proteins serve as matrices associated with intermediate filaments and vary between species, with nutritional status affecting their abundance in sheep. HGT proteins were not found in human hair, suggesting modulation in their expression. UHS proteins, with high cysteine content, increase in expression with more available cysteine. A human UHS gene was isolated for further study. Trichohyalin protein, found in the inner root sheath, undergoes significant changes during cell differentiation. The study also noted arginyl-tRNA transferase activity in hair follicles, which may play a role in protein processing.
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