Iε-(γ-Glutamyl) Lysine Cross-Linkage in Citrulline-Containing Protein Fractions From Hair

February 1971 in “ Biochemistry ”

Harry W.J. Harding, George E. Rogers

iε-(γ-Glutamyl) lysine citrulline arginine deimination hair protein protein cross-linkage

TLDR Specific cross-linkages help make hair proteins stable and strong.

The 1971 study by George E. Rogers explored the biochemical properties of hair proteins, specifically examining the presence of iε-(γ-Glutamyl) lysine cross-linkages in citrulline-containing protein fractions. Citrulline is formed through the enzymatic deimination of arginine residues, and this research enhanced the understanding of hair protein structure and the biochemical processes involved in hair formation and maintenance.

View this study on pubs.acs.org →

Discuss this study in the Community →

Related Community Posts Join

6 / 1000+ results

community I took Min as a precautionary measure and to try to increase hair growth, now I’m suffering from a severely altered hair cycle

in General 106 upvotes 1 week ago

Minoxidil use led to a disrupted hair cycle and hair damage. The user seeks ways to restore normal hair growth.

community I have a diffuse thinning alopecia, what you see is a custom full cap wig. Happy to answer questions! Im very active and have never had an issue!

in Hair Systems 131 upvotes 2 weeks ago

A user with diffuse thinning alopecia uses a custom full cap wig for an active lifestyle, costing $450 and lasting about 10 months. They share their positive experience with the wig as an alternative for those for whom treatments like Minoxidil, finasteride, or RU58841 don't work.

community I quit oral min during in shedding phase

in Minoxidil 3 weeks ago

The user stopped using oral minoxidil due to shedding and is continuing with oral finasteride and hair vitamins. They are advised that shedding is temporary and to maintain finasteride use, with examples of others successfully managing hair loss with similar treatments.

community I’m balding at 17

in General 115 upvotes 3 weeks ago

A 17-year-old is experiencing hair loss and is considering using Minoxidil and Finasteride. They are questioning if Minoxidil alone is sufficient or if Finasteride is necessary.

community I quit Oral Finasterise over a year ago and here's what I've found

in Finasteride/Dutasteride 52 upvotes 3 weeks ago

The user quit oral finasteride over a year ago, experienced improvements in brain fog and erectile dysfunction after quitting smoking and porn, and plans to try dutasteride. Another user shared their experience with finasteride, mentioning panic attacks and anxiety, and managed symptoms through lifestyle changes like meditation and exercise.

community I need help. I’m 21M and doing PRP Treatment and Finasteride

in Is this regrowth? 1 upvotes 1 month ago

A 21-year-old male is experiencing hair thinning and has undergone PRP treatment while considering finasteride but is concerned about its side effects. A user suggests that PRP is ineffective without finasteride and advises against using biotin.

Similar Research

5 / 1000+ results

research The Fate of Trichohyalin

135 citations , October 1997 in “Journal of biological chemistry/The Journal of biological chemistry”

Trichohyalin is modified by enzymes to form strong structures in hair cells.

research Formation of the Iε-(γ-Glutamyl)Lysine Crosslink in Hair Proteins: Investigation of Transamidases in Hair Follicles

59 citations , July 1972 in “Biochemistry”

Transamidases help form strong crosslinks in hair proteins, crucial for hair strength.

research Specific Citrullination Causes Assembly of a Globular S100A3 Homotetramer

62 citations , December 2007 in “Journal of biological chemistry/The Journal of biological chemistry”

A specific chemical change in the S100A3 protein leads to the formation of a four-part structure important for hair formation.

research Proteome Analysis of Human Hair Shaft

122 citations , January 2006 in “Molecular & Cellular Proteomics”

Human hair contains many proteins, with some being highly abundant and modified.

research Wanted, Dead and Alive: Why a Multidisciplinary Approach Is Needed to Unlock Hair Treatment Potential

21 citations , February 2019 in “Experimental Dermatology”

Different fields of expertise must work together to better understand hair growth and create effective hair loss treatments.