Proteome Analysis of Human Hair Shaft
January 2006
in “
Molecular & Cellular Proteomics
”
TLDR Human hair contains many proteins, with some being highly abundant and modified.
The study conducted a comprehensive proteome analysis of the human hair shaft, identifying 343 proteins from three hair samples. It revealed a complex array of proteins involved in various cellular functions, with keratins and keratin-associated proteins being the most abundant. The research highlighted the presence of structural proteins and posttranslational modifications such as methylation, dimethylation, and ubiquitination, which were significant for understanding hair biogenesis and the molecular basis of hair and skin disorders. The study also emphasized the role of transglutaminases in protein cross-linking, crucial for hair shaft stabilization, and suggested potential noninvasive diagnostic applications for genetic hair or skin diseases.
