Transglutaminase from Hair Follicle of Guinea Pig

    February 1972 in “ Proceedings of the National Academy of Sciences ”
    Soo Im Chung, J.E. Folk
    TLDR A unique enzyme in guinea pig hair follicles helps form protein cross-links in hair.
    The study identified two transglutaminases in the inner root sheaths of guinea pig hair follicles. One enzyme was similar to liver transglutaminase, while the other, more abundant enzyme was unique to hair follicles. This hair-follicle enzyme, with a molecular weight of 54,000, consisted of two identical subunits. It catalyzed the cross-linking of fibrin and fibrinogen through ε(γ-glutamyl)lysine bonds, suggesting its role in forming protein cross-links in hair.
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