TLDR Transglutaminases help form strong hair by linking proteins, and can potentially alter hair properties.
The document discussed the role of transglutaminases, which are calcium-dependent enzymes, in the formation of normal hair by cross-linking proteins in the hair follicle. These enzymes form covalent bonds between specific amino acid residues, contributing to the structural integrity of hair. The study highlighted that structural analogues of natural substrates could be incorporated into hair, potentially altering its properties. The research also differentiated between epidermal and follicular transglutaminases, noting their biochemical and immunological differences, and suggested the possibility of selectively modifying hair or epidermal proteins through transglutaminase-mediated procedures.
53 citations
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June 1983 in “Journal of Investigative Dermatology” The enzyme is crucial for skin cell development and can be activated without proteolytic activation.
138 citations
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November 1977 in “Biochimica et Biophysica Acta (BBA) - Proteins and Proteomics” 138 citations
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December 1976 in “Journal of Biological Chemistry” The enzyme from human skin can cross-link proteins and needs calcium to work.
59 citations
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July 1972 in “Biochemistry” Transamidases help form strong crosslinks in hair proteins, crucial for hair strength.
103 citations
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February 1972 in “Proceedings of the National Academy of Sciences” A unique enzyme in guinea pig hair follicles helps form protein cross-links in hair.
49 citations
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January 1972 in “Biochimica et Biophysica Acta (BBA) - Protein Structure” 125 citations
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February 1971 in “Biochemistry” Specific cross-linkages help make hair proteins stable and strong.
February 2025 in “Animals” Understanding proteins in skin structures like claws and hair is crucial for future research.
57 citations
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January 2020 in “International Journal of Molecular Sciences” PADs are crucial for healthy skin and hair, and their imbalance can cause skin and hair disorders.
35 citations
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July 2010 in “The FEBS journal” The study found a specific peptide that helps detect TGase 3 activity in skin and hair follicles.
40 citations
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January 2016 in “Elsevier eBooks” The skin is the largest organ, protecting the body, regulating temperature, and producing hormones.
30 citations
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August 2008 in “The journal of investigative dermatology/Journal of investigative dermatology” TGase 3 helps build hair structure by forming strong bonds between proteins.
