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GlossaryTransglutaminase

enzyme that cross-links proteins, crucial for hair strength

Transglutaminase, often abbreviated as TGase, is an enzyme that catalyzes the formation of covalent bonds between proteins, specifically by linking the amino acid glutamine to lysine. This process is crucial for various biological functions, including blood clotting, skin formation, and hair follicle development. In the context of hair, transglutaminase helps strengthen the hair shaft by cross-linking keratin proteins, contributing to hair's structural integrity and resilience.

Related Terms

Learn

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learn glutamic acid

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Research

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research Transglutaminase from Hair Follicle of Guinea Pig

103 citations , February 1972 in “Proceedings of the National Academy of Sciences”

A unique enzyme in guinea pig hair follicles helps form protein cross-links in hair.

research Kinetic Studies with Transglutaminases

91 citations , May 1972 in “Journal of Biological Chemistry”

Transglutaminases work through a ping-pong mechanism, and human plasma and platelet transglutaminases have similar catalytic subunits.

research Identification of a preferred substrate peptide for transglutaminase 3 and detection of in situ activity in skin and hair follicles

35 citations , July 2010 in “The FEBS journal”

The study found a specific peptide that helps detect TGase 3 activity in skin and hair follicles.

research Transglutaminase-3 Enzyme: A Putative Actor in Human Hair Shaft Scaffolding?

30 citations , August 2008 in “The journal of investigative dermatology/Journal of investigative dermatology”

TGase 3 helps build hair structure by forming strong bonds between proteins.

research Transglutaminase 5 Expression in Human Hair Follicle

28 citations , August 2005 in “Journal of Investigative Dermatology”

TG5 helps maintain hair follicle health, while TG3 aids in hair shaft development.

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Community Join

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community TGF-Beta. Good or Bad? Help for treatment investment

in Treatment 12 upvotes 3 years ago

TGF-B affects hair growth, both causing stem cell division and death depending on amounts. Amplifica's treatment injects Scube3 to increase TGF-B for hair growth.

community Best Treatment In The Pipeline?

in Chat 15 upvotes 1 year ago

New treatments for AGA are emerging, including pyrilutumide, gt0029, scube3, kx-826, and pp405. Verteporfin is mentioned as a promising option.

community Peptide Therapy -> GHK-CU, ZN-Thumulin, PTD-DBM

in Research/Science 4 upvotes 2 years ago

The conversation is about the use of peptide therapies for hair loss, specifically GHK-CU, ZN-Thymulin, and PTD-DBM. The user is seeking feedback on the effectiveness of these treatments from those who have tried them.

community Can amino acids help with AGA

in Chat 4 upvotes 2 years ago

Amino acids like lysine, methionine, and cysteine may help with androgenetic alopecia when taken in high doses along with a DHT blocker. Users discuss combining these with treatments like Minoxidil, finasteride, and RU58841.

community Methionine? Glycine?

4 upvotes 10 years ago

The conversation discusses the potential benefits and risks of using Methionine and Glycine for hair loss, with concerns about cancer risk if not balanced properly. The user seeks opinions on these amino acids for hair health and overall benefits.

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