Search

for
Search:

GlossaryLegumain

enzyme that breaks down proteins in acidic cell environments

Legumain is an enzyme that plays a crucial role in breaking down proteins within cells. It is particularly active in acidic environments, such as those found in lysosomes, and is involved in various biological processes, including immune response and tissue remodeling. For professionals, it's noteworthy that legumain is an asparaginyl endopeptidase, which means it specifically cleaves peptide bonds at asparagine residues.

Related Terms

Learn

0 / 0 results

— no results

Research

5 / 126 results

research Cystatin M/E Is a High Affinity Inhibitor of Cathepsin V and Cathepsin L by a Reactive Site Distinct from the Legumain-binding Site

100 citations , March 2006 in “Journal of biological chemistry/The Journal of biological chemistry”

Cystatin M/E strongly inhibits cathepsin V and cathepsin L, important for skin formation.

research Epidermal Differentiation: The Role of Proteases and Their Inhibitors

118 citations , January 2004 in “European Journal of Cell Biology”

Balanced protease activity is crucial for healthy skin and hair development.

research Colocalization of Cystatin M/E and Its Target Proteases Suggests a Role in Terminal Differentiation of Human Hair Follicle and Nail

22 citations , November 2008 in “The journal of investigative dermatology/Journal of investigative dermatology”

Cystatin M/E helps in the final stages of hair and nail formation by controlling certain enzymes.

research Deficiency of the Human Cysteine Protease Inhibitor Cystatin M/E Causes Hypotrichosis and Dry Skin

10 citations , November 2018 in “Genetics in medicine”

Lack of cystatin M/E causes thin hair and dry skin.

research Deficiency of the Human Cysteine Protease Inhibitor Cystatin M/E Causes Hypotrichosis and Dry Skin

September 2019 in “The journal of investigative dermatology/Journal of investigative dermatology”

Not having enough cystatin M/E protein causes less hair growth and dry skin.

View more "legumain" in research →

Community Join

0 / 0 results

— no results