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GlossaryLegumain

enzyme that breaks down proteins in acidic cell environments

Legumain is an enzyme that plays a crucial role in breaking down proteins within cells. It is particularly active in acidic environments, such as those found in lysosomes, and is involved in various biological processes, including immune response and tissue remodeling. For professionals, it's noteworthy that legumain is an asparaginyl endopeptidase, which means it specifically cleaves peptide bonds at asparagine residues.

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research Cystatin M/E Is a High Affinity Inhibitor of Cathepsin V and Cathepsin L by a Reactive Site Distinct from the Legumain-binding Site

100 citations, March 2006 in “Journal of biological chemistry/The Journal of biological chemistry”

Cystatin M/E strongly inhibits cathepsin V and cathepsin L, important for skin formation.

research Colocalization of Cystatin M/E and Its Target Proteases Suggests a Role in Terminal Differentiation of Human Hair Follicle and Nail

22 citations, November 2008 in “The journal of investigative dermatology/Journal of investigative dermatology”

Cystatin M/E helps in the final stages of hair and nail formation by controlling certain enzymes.

research Deficiency of the Human Cysteine Protease Inhibitor Cystatin M/E Causes Hypotrichosis and Dry Skin

10 citations, November 2018 in “Genetics in medicine”

Lack of cystatin M/E causes thin hair and dry skin.

research Deficiency of the Human Cysteine Protease Inhibitor Cystatin M/E Causes Hypotrichosis and Dry Skin

September 2019 in “The journal of investigative dermatology/Journal of investigative dermatology”

Not having enough cystatin M/E protein causes less hair growth and dry skin.

research Cornification

September 2018

Cornification is the process where living skin cells die to create a protective barrier, and problems with it can cause skin diseases.

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