TLDR TG5 helps maintain hair follicle health, while TG3 aids in hair shaft development.
The study investigated the expression of transglutaminase enzymes, focusing on TG5, in human hair follicles. TG5 was expressed during hair follicle homeostasis and had a distribution similar to involucrin, suggesting its role in keratinization of the inner root sheath. TG1 and TG5 were found to cooperate in hair follicle development, contributing to cornified cell envelope formation. TG3, however, showed a distinct pattern, being specific to the hair shaft and cuticle, indicating its role in hair shaft differentiation. The study suggested that TG5 and TG3 played roles in hair structure cross-linking and differentiation, with TG5 contributing to follicle homeostasis and TG3 to shaft development.
130 citations
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April 2003 in “Journal of Investigative Dermatology” Four specific keratins in hair follicles help understand hair structure and function.
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