Deimination and Peptidylarginine Deiminases in Skin Physiology and Diseases

    January 2020 in “ International Journal of Molecular Sciences ”
    Marie‐Claire Méchin, Hidenari Takahara, Michel Simon
    TLDR PADs are crucial for healthy skin and hair, and their imbalance can cause skin and hair disorders.
    The document discussed the role of deimination, a post-translational modification catalyzed by peptidylarginine deiminases (PADs), in skin physiology and diseases. It highlighted the involvement of PADs in processes such as keratinocyte differentiation and the maintenance of the epidermal barrier, as well as their impact on hair follicles. Altered PAD activity in the hair shaft was linked to hair disorders like uncombable hair syndrome and a specific form of inflammatory scarring alopecia, predominantly affecting women of African ancestry. The study emphasized the significance of PADs in both skin homeostasis and various skin-related diseases.
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