Deimination and Peptidylarginine Deiminases in Skin Physiology and Diseases

    January 2020 in “ International Journal of Molecular Sciences ”
    Marie‐Claire Méchin, Hidenari Takahara, Michel Simon
    TLDR PADs are crucial for healthy skin and hair, and their imbalance can cause skin and hair disorders.
    The review discussed the role of deimination and peptidylarginine deiminases (PADs) in skin physiology and diseases, with a focus on hair disorders. It highlighted the involvement of PADs in keratinocyte differentiation, epidermal barrier function, and hair follicles. Altered PAD activity was linked to uncombable hair syndrome and inflammatory scarring alopecia, particularly affecting women of African ancestry. PAD1, PAD2, and PAD3 were the main isotypes detected, with PAD3 mutations associated with Uncombable Hair Syndrome and Central Centrifugal Cicatricial Alopecia. The study emphasized the genetic basis of these conditions and the role of the trichohyalin-PAD3-TGase 3 pathway in hair follicle physiology, suggesting potential therapeutic targets for skin and hair disorders.
    Discuss this study in the Community →

    Research cited in this study

    9 / 9 results

    Related Community Posts Join

    6 / 26 results

      community Is my brother balding or am I delusional?

      in Satire  939 upvotes 5 months ago
      The conversation humorously discusses hair loss treatments, suggesting minoxidil, finasteride, dutasteride, nizoral shampoo, and various unconventional methods. It also includes jokes about hairlines and the effectiveness of these treatments.

      community Can we divert DHT from head to ass hair?

      in Satire  163 upvotes 5 months ago
      The conversation humorously discusses diverting DHT from head to body hair and explores the idea of transplanting body hair to the scalp. It also mentions the potential for treatments to prevent DHT from affecting hair follicles.

      community Kintor does not have abandoned KX-826 - ANNUAL RESULTS 2023

      in Product  7 upvotes 1 year ago
      The conversation discusses disappointment with the hair loss treatment KX-826 but notes that the company Kintor is still focused on developing and commercializing it, as stated in their 2023 annual report. The user questions the effectiveness of KX-826 in comparison to minoxidil's role in improving hair thickness and appearance.

      community Went for hair transplant. 3200 grafts.

      in Transplants  320 upvotes 2 years ago
      A user underwent a hair transplant with 3200 grafts and plans to update others on their progress. They previously used minoxidil and finasteride to stabilize hair loss but opted for a transplant for better results.

    Similar Research

    5 / 1000+ results