Deimination and Peptidylarginine Deiminases in Skin Physiology and Diseases

    January 2020 in “ International Journal of Molecular Sciences ”
    Marie‐Claire Méchin, Hidenari Takahara, Michel Simon
    TLDR PADs are crucial for healthy skin and hair, and their imbalance can cause skin and hair disorders.
    The review discussed the role of deimination and peptidylarginine deiminases (PADs) in skin physiology and diseases, with a focus on hair disorders. It highlighted the involvement of PADs in keratinocyte differentiation, epidermal barrier function, and hair follicles. Altered PAD activity was linked to uncombable hair syndrome and inflammatory scarring alopecia, particularly affecting women of African ancestry. PAD1, PAD2, and PAD3 were the main isotypes detected, with PAD3 mutations associated with Uncombable Hair Syndrome and Central Centrifugal Cicatricial Alopecia. The study emphasized the genetic basis of these conditions and the role of the trichohyalin-PAD3-TGase 3 pathway in hair follicle physiology, suggesting potential therapeutic targets for skin and hair disorders.
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