Distinguishing Mouse Strains by Proteomic Analysis of Pelage Hair

March 2009 in “ Journal of Investigative Dermatology ”

Robert H. Rice, David M. Rocke, Hua-Sheng Tsai, Kathleen A. Silva, Young‐Jin Lee, John P. Sundberg

proteomic analysis pelage hair trichohyalin cortical cell projections hair defect genetic variations hair structure molecular basis of hair defects

TLDR Proteomic analysis can identify genetic differences in mouse hair, helping understand hair defects and variations.

The study used proteomic analysis to investigate differences in pelage hair among three mouse strains: AKR/J-hid/hid, FVB/NJ+/+, and LP/J+/+. It identified 111 proteins in AKR/J-hid/hid mice, highlighting deficiencies in cortical cell projections and lower trichohyalin levels, which may contribute to their hair defect. Significant differences in 65 proteins were found across the strains, with AKR/J mice showing unique proteins not present in others. The research demonstrated the utility of proteomic analysis in distinguishing genetic variations in hair structure and provided insights into the molecular basis of hair defects, suggesting potential applications for understanding human hair variations.

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Distinguishing Mouse Strains by Proteomic Analysis of Pelage Hair

Research cited in this study

research Hair Follicle-Specific Keratins And Their Diseases

research Novel Type I Hair Keratins K39 And K40 Are The Last To Be Expressed In Differentiation Of The Hair: Completion Of The Human Hair Keratin Catalog

research K25 (K25irs1), K26 (K25irs2), K27 (K25irs3), And K28 (K25irs4) Represent The Type I Inner Root Sheath Keratins Of The Human Hair Follicle

research Proteome Analysis of Human Hair Shaft

research Type II Epithelial Keratin 6hf (K6hf) Is Expressed in the Companion Layer, Matrix, and Medulla in Anagen-Stage Hair Follicles

research The Catalog of Human Hair Keratins

research The Catalog of Human Hair Keratins

research Cross-Linked Features of Mouse Pelage Hair Resistant to Detergent Extraction

research Ultrastructural Visualization of Cross-Linked Protein Features in Epidermal Appendages

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