TLDR Inhibiting ALOX12 can help hair cuticle maturation by increasing S100A3 citrullination.
The study demonstrated that several naturally occurring compounds, such as hinokitiol, escletin, and quercetin, increased S100A3 citrullination in SW480 cells and promoted cuticular differentiation in isolated human hair follicles. These effects were linked to the inhibition of arachidonate 12-lipoxygenase (ALOX12), which up-regulated heparin-binding epidermal growth factor-like growth factor (HBEGF) and regulated PADI gene expression. Additionally, arachidonic acid promoted S100A3 citrullination and elevated HBEGF in isolated hair follicles, suggesting that ALOX12 inhibition could effectively trigger hair cuticle maturation by modulating arachidonate metabolism in conjunction with HBEGF.
Cited in this study
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