Arachidonate 12-Lipoxygenase Inhibitors Promote S100A3 Citrullination in Cultured SW480 Cells and Isolated Hair Follicles

    Kenji Kizawa, Takeshi Fujimori, Tomomitsu Kawai
    Studysummary This study found that inhibiting arachidonate 12-lipoxygenase (ALOX12) may enhance hair cuticle maturation by increasing S100A3 protein citrullination and promoting cuticular differentiation in isolated human hair follicles.
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    Research cited in this study 8

    1. Mutations in Three Genes Encoding Proteins Involved in Hair Shaft Formation Cause Uncombable Hair Syndrome American journal of human genetics · 2016
    2. Human Hair Follicle Organ Culture: Theory, Application, and Perspectives Experimental Dermatology · 2015
    3. A Two-Step Culture Method for Efficient Production of Trichogenic Keratinocytes Tissue Engineering Part C-methods · 2015
    4. Importance of Citrullination on Hair Protein Molecular Assembly During Trichocytic Differentiation 2013
    5. Specific Citrullination Causes Assembly of a Globular S100A3 Homotetramer Journal of biological chemistry/˜The œJournal of biological chemistry · 2007
    6. Failure of Intercellular Adhesion in Hair Fibers Regarding Hair Condition and Strain Conditions International Journal of Cosmetic Science · 2004
    7. The Use of Dermal Papilla Cells in Studies of Normal and Abnormal Hair Follicle Biology Dermatologic Clinics · 1996
    8. Modulation of the Differentiated Phenotype of Keratinocytes of the Hair Follicle and Epidermis Journal of Dermatological Science · 1994