TLDR Inhibiting ALOX12 can help hair cuticle maturation by increasing S100A3 citrullination.
The study demonstrated that several naturally occurring compounds, such as hinokitiol, escletin, and quercetin, increased S100A3 citrullination in SW480 cells and promoted cuticular differentiation in isolated human hair follicles. These effects were linked to the inhibition of arachidonate 12-lipoxygenase (ALOX12), which up-regulated heparin-binding epidermal growth factor-like growth factor (HBEGF) and regulated PADI gene expression. Additionally, arachidonic acid promoted S100A3 citrullination and elevated HBEGF in isolated hair follicles, suggesting that ALOX12 inhibition could effectively trigger hair cuticle maturation by modulating arachidonate metabolism in conjunction with HBEGF.
119 citations,
November 2016 in “American journal of human genetics” Mutations in three genes cause Uncombable Hair Syndrome, leading to frizzy hair that can't be combed flat.
130 citations,
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62 citations,
December 2007 in “Journal of biological chemistry/The Journal of biological chemistry” A specific chemical change in the S100A3 protein leads to the formation of a four-part structure important for hair formation.
7 citations,
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54 citations,
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32 citations,
January 2008 in “Journal of Microencapsulation” Cosmetics with hinokitiol-loaded nanocapsules were found to effectively promote hair growth.
5 citations,
February 2010 in “Drug development and industrial pharmacy” Vesicles made of behenyltrimethylammonium chloride and stearic acid can triple the skin absorption of hinokitiol, which may help with hair growth.
4 citations,
May 2007 in “Journal of Dispersion Science and Technology” Hinokitiol in cationic vesicles promotes hair growth better due to higher skin retention.
1 citations,
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