Arachidonate 12-Lipoxygenase Inhibitors Promote S100A3 Citrullination in Cultured SW480 Cells and Isolated Hair Follicles

January 2017 in “ Biological & pharmaceutical bulletin ”

Kenji Kizawa, Takeshi Fujimori, Tomomitsu Kawai

hinokitiol escletin quercetin S100A3 citrullination SW480 cells hair follicles arachidonate 12-lipoxygenase ALOX12 heparin-binding epidermal growth factor-like growth factor HBEGF PADI gene expression arachidonic acid hair cuticle maturation arachidonate metabolism S100A3 PADI hair cuticle

TLDR Inhibiting ALOX12 can help hair cuticle maturation by increasing S100A3 citrullination.

The study demonstrated that several naturally occurring compounds, such as hinokitiol, escletin, and quercetin, increased S100A3 citrullination in SW480 cells and promoted cuticular differentiation in isolated human hair follicles. These effects were linked to the inhibition of arachidonate 12-lipoxygenase (ALOX12), which up-regulated heparin-binding epidermal growth factor-like growth factor (HBEGF) and regulated PADI gene expression. Additionally, arachidonic acid promoted S100A3 citrullination and elevated HBEGF in isolated hair follicles, suggesting that ALOX12 inhibition could effectively trigger hair cuticle maturation by modulating arachidonate metabolism in conjunction with HBEGF.

View this study on jstage.jst.go.jp →

Discuss this study in the Community →

Research cited in this study

6 / 6 results

Similar Research

5 / 31 results

research Hinokitiol, a Natural Tropolone Derivative, Inhibits TNF-α Production in LPS-Activated Macrophages via Suppression of NF-κB

54 citations, June 2008 in “Planta Medica”

research In Vivo Hair Growth Promotion Effects of Cosmetic Preparations Containing Hinokitiol-Loaded Poly(ε-Caprolactone) Nanocapsules

32 citations, January 2008 in “Journal of Microencapsulation”

Cosmetics with hinokitiol-loaded nanocapsules were found to effectively promote hair growth.

research In Vitro Skin Permeation of Hinokitiol Loaded in Vesicles Composed of Behenyltrimethylammonium Chloride and Stearic Acid

5 citations, February 2010 in “Drug development and industrial pharmacy”

Vesicles made of behenyltrimethylammonium chloride and stearic acid can triple the skin absorption of hinokitiol, which may help with hair growth.

research After-Rinsing Hair Growth Promotion of Hinokitiol-Containing Vesicles and Emulsions

4 citations, May 2007 in “Journal of Dispersion Science and Technology”

Hinokitiol in cationic vesicles promotes hair growth better due to higher skin retention.

research Two Cases of Allergic Contact Dermatitis to Hinokitiol and Pantothenylethylether in Hair Growth Promoter

1 citations, January 1997 in “Skin research”

Arachidonate 12-Lipoxygenase Inhibitors Promote S100A3 Citrullination in Cultured SW480 Cells and Isolated Hair Follicles

Research cited in this study

research Mutations in Three Genes Encoding Proteins Involved in Hair Shaft Formation Cause Uncombable Hair Syndrome

research Human Hair Follicle Organ Culture: Theory, Application, and Perspectives

research A Two-Step Culture Method for Efficient Production of Trichogenic Keratinocytes

research Specific Citrullination Causes Assembly of a Globular S100A3 Homotetramer

research Failure of Intercellular Adhesion in Hair Fibers Regarding Hair Condition and Strain Conditions