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This study found that inhibiting arachidonate 12-lipoxygenase (ALOX12) may enhance hair cuticle maturation by increasing S100A3 protein citrullination and promoting cuticular differentiation in isolated human hair follicles.

This study found that pure linoleate deficiency in rats caused significant reductions in the accumulation of n-6 polyunsaturates and mild symptoms like growth retardation, compared to classical essential fatty acid deficiency.

This study found that prostaglandin metabolism enzymes are present in human hair follicles, suggesting a potential role in hair growth and differentiation, with some expression differences between men and women.

This study found that FLCN deficiency in mice muscles led to increased mitochondrial biogenesis and a metabolic shift towards oxidative phosphorylation, with a similar advantage observed in FLCN-null kidney cancer cells.

This study found that biotransformation of finasteride by Aspergillus niger produced two metabolites with different levels of lipoxygenase inhibition, suggesting potential for developing more potent derivatives.