Production of Biologically Active Oxidized Derivatives of Finasteride Through Metabolism by Aspergillus Niger Culture
May 2016
in “
Pharmaceutical Biology
”
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Studysummary This study found that biotransformation of finasteride by Aspergillus niger produced two metabolites with different levels of lipoxygenase inhibition, suggesting potential for developing more potent derivatives.
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The study investigated the biotransformation of finasteride by Aspergillus niger culture to produce biologically active oxidized derivatives. Two metabolites were identified and characterized as 11a-hydroxyfinasteride and 15ß-hydroxyfinasteride, which were found to possess inhibitory effects on lipoxygenase enzyme. The study suggests that the biological potential of a compound can be improved through microbial technology.
