Production of Biologically Active Oxidized Derivatives of Finasteride Through Metabolism by Aspergillus Niger Culture

    May 2016 in “ Pharmaceutical Biology ”
    Sajid Ali, Muhammad Farrukh Nisar, Zarbad Shah
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    TLDR Aspergillus niger culture creates two finasteride derivatives with enzyme-inhibiting effects.
    The study investigated the biotransformation of finasteride by Aspergillus niger culture to produce biologically active oxidized derivatives. Two metabolites were identified and characterized as 11a-hydroxyfinasteride and 15ß-hydroxyfinasteride, which were found to possess inhibitory effects on lipoxygenase enzyme. The study suggests that the biological potential of a compound can be improved through microbial technology.
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