Production of Biologically Active Oxidized Derivatives of Finasteride Through Metabolism by Aspergillus Niger Culture

May 2016 in “ Pharmaceutical Biology ”

Sajid Ali, Muhammad Farrukh Nisar, Zarbad Shah

finasteride 11a-hydroxyfinasteride 15ß-hydroxyfinasteride lipoxygenase biotransformation Aspergillus niger Propecia

TLDR Aspergillus niger culture creates two finasteride derivatives with enzyme-inhibiting effects.

The study investigated the biotransformation of finasteride by Aspergillus niger culture to produce biologically active oxidized derivatives. Two metabolites were identified and characterized as 11a-hydroxyfinasteride and 15ß-hydroxyfinasteride, which were found to possess inhibitory effects on lipoxygenase enzyme. The study suggests that the biological potential of a compound can be improved through microbial technology.

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Related Research

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research Production of Biologically Active Oxidized Derivatives of Finasteride Through Metabolism by Aspergillus Niger Culture

1 citations, May 2016 in “Pharmaceutical Biology”

Aspergillus niger culture creates two finasteride derivatives with enzyme-inhibiting effects.

Biotransformation of Finasteride by Ocimum Sanctum L., and Tyrosinase Inhibitory Activity of Transformed Metabolites: Experimental and Computational Insights

research Biotransformation of Finasteride by Ocimum Sanctum L., and Tyrosinase Inhibitory Activity of Transformed Metabolites: Experimental and Computational Insights

3 citations, December 2014 in “Steroids”

Fermentation of Finasteride with Ocimum sanctum L. creates new metabolite that inhibits tyrosinase.