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Glossary PADI3

enzyme crucial for hair shaft formation and maintenance

PADI3 stands for Peptidyl Arginine Deiminase, Type III, an enzyme that plays a crucial role in the formation and maintenance of hair. It modifies certain proteins in hair follicles, which is essential for proper hair shaft formation. Mutations in the PADI3 gene can lead to hair disorders such as uncombable hair syndrome, characterized by dry, frizzy hair that is resistant to being combed flat.

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research A Hairy Cituation – PADIs in Regeneration and Alopecia

5 citations , December 2021 in “Frontiers in Cell and Developmental Biology”

This review outlines how peptidyl arginine deiminases (PADIs) and protein citrullination are involved in hair follicle regeneration and inflammatory alopecia, but presents no new clinical findings.

research Co-expression of PADI isoforms during progenitor differentiation enables functional diversity

2 citations , October 2023 in “Philosophical Transactions of the Royal Society B Biological Sciences”

This study identified novel isoforms of the PADI2 and PADI3 proteins, showing that PADI2β inhibits oligodendrocyte differentiation, possibly by opposing the effect of canonical PADI2, while PADI3β modulates the activity of PADI3α, suggesting new regulatory mechanisms of citrullination in tissue development.

research The citrullinating enzyme PADI4 governs progenitor cell proliferation and translation in developing hair follicles

September 2025 in “Science Advances”

This study reports that PADI4, an enzyme involved in posttranslational protein modifications, regulates progenitor cell transitions in hair follicle development by repressing transcription and interacting with translational and ribosomal processes.

research Mutations in Three Genes Encoding Proteins Involved in Hair Shaft Formation Cause Uncombable Hair Syndrome

119 citations , November 2016 in “American journal of human genetics”

This study reports the discovery of mutations in the PADI3, TGM3, and TCHH genes as molecular genetic causes of uncombable hair syndrome in children, indicating an autosomal-recessive inheritance pattern.

research Variant PADI3 in Central Centrifugal Cicatricial Alopecia

95 citations , February 2019 in “The New England Journal of Medicine”

This article discusses the potential genetic basis of central centrifugal cicatricial alopecia in women of African ancestry but does not provide new research results.

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Related Terms

Research

research A Hairy Cituation – PADIs in Regeneration and Alopecia

research Co-expression of PADI isoforms during progenitor differentiation enables functional diversity

research The citrullinating enzyme PADI4 governs progenitor cell proliferation and translation in developing hair follicles

research Mutations in Three Genes Encoding Proteins Involved in Hair Shaft Formation Cause Uncombable Hair Syndrome

research Variant PADI3 in Central Centrifugal Cicatricial Alopecia

Experts

Padideh Sarjoghian, دارنده مدرک امگل شناسی و قارچ شناسی از دانشگاه علوم پزشکی

Carolina Padilha, MD

Elvira Padilla

Liliana Padilla

Nayra Aviña Padilla

Andrea Claudie Márquez Padilla Estremo

Clinics

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