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    Glossary PADI1

    enzyme that modifies proteins, affecting hair and skin health

    PADI1 stands for Peptidyl Arginine Deiminase Type 1, an enzyme that plays a role in the post-translational modification of proteins by converting arginine residues into citrulline. This process, known as citrullination, is important for the regulation of gene expression and the structural integrity of hair and skin. Mutations in the PADI1 gene can lead to skin and hair disorders, including certain forms of alopecia.

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    Research 10 of 496

    1. A Hairy Cituation – PADIs in Regeneration and Alopecia Frontiers in Cell and Developmental Biology · 2021 · 5 citations
    2. The citrullinating enzyme PADI4 governs progenitor cell proliferation and translation in developing hair follicles Science Advances · 2025
    3. Co-expression of PADI isoforms during progenitor differentiation enables functional diversity Philosophical Transactions of the Royal Society B Biological Sciences · 2023 · 2 citations
    4. Mutations in Three Genes Encoding Proteins Involved in Hair Shaft Formation Cause Uncombable Hair Syndrome American journal of human genetics · 2016 · 119 citations
    5. Peptidylarginine Deiminase Isoforms Are Differentially Expressed in the Anagen Hair Follicles and Other Human Skin Appendages Journal of Investigative Dermatology · 2005 · 71 citations
    6. Reciprocal role of vitamin D receptor on β-catenin regulated keratinocyte proliferation and differentiation The Journal of Steroid Biochemistry and Molecular Biology · 2013 · 49 citations
    7. Mapping of cis-acting expression quantitative trait loci in human scalp hair follicles BMC Dermatology · 2020 · 4 citations
    8. Citrullination at the Inflammatory Skin Barrier 2023
    9. Unravelling the threads of central centrifugal cicatricial alopecia Journal of Investigative Dermatology · 2026
    10. Variant <i>PADI3</i> in Central Centrifugal Cicatricial Alopecia The New England Journal of Medicine · 2019 · 95 citations
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