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    Glossary PADI1

    enzyme that modifies proteins, affecting hair and skin health

    PADI1 stands for Peptidyl Arginine Deiminase Type 1, an enzyme that plays a role in the post-translational modification of proteins by converting arginine residues into citrulline. This process, known as citrullination, is important for the regulation of gene expression and the structural integrity of hair and skin. Mutations in the PADI1 gene can lead to skin and hair disorders, including certain forms of alopecia.

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    Research 30 of 496

    1. A Hairy Cituation – PADIs in Regeneration and Alopecia Frontiers in Cell and Developmental Biology · 2021 · 5 citations
    2. The citrullinating enzyme PADI4 governs progenitor cell proliferation and translation in developing hair follicles Science Advances · 2025
    3. Co-expression of PADI isoforms during progenitor differentiation enables functional diversity Philosophical Transactions of the Royal Society B Biological Sciences · 2023 · 2 citations
    4. Mutations in Three Genes Encoding Proteins Involved in Hair Shaft Formation Cause Uncombable Hair Syndrome American journal of human genetics · 2016 · 119 citations
    5. Peptidylarginine Deiminase Isoforms Are Differentially Expressed in the Anagen Hair Follicles and Other Human Skin Appendages Journal of Investigative Dermatology · 2005 · 71 citations
    6. Reciprocal role of vitamin D receptor on β-catenin regulated keratinocyte proliferation and differentiation The Journal of Steroid Biochemistry and Molecular Biology · 2013 · 49 citations
    7. Mapping of cis-acting expression quantitative trait loci in human scalp hair follicles BMC Dermatology · 2020 · 4 citations
    8. Citrullination at the Inflammatory Skin Barrier 2023
    9. Unravelling the threads of central centrifugal cicatricial alopecia Journal of Investigative Dermatology · 2026
    10. Variant <i>PADI3</i> in Central Centrifugal Cicatricial Alopecia The New England Journal of Medicine · 2019 · 95 citations
    11. Skin transcriptome profiling of Changthangi goats highlights the relevance of genes involved in Pashmina production Scientific reports · 2020 · 22 citations
    12. Genetic Susceptibility to Alopecia The New England Journal of Medicine · 2019 · 5 citations
    13. Arachidonate 12-Lipoxygenase Inhibitors Promote S100A3 Citrullination in Cultured SW480 Cells and Isolated Hair Follicles Biological & pharmaceutical bulletin · 2017 · 4 citations
    14. Two siblings with uncombable hair syndrome: A new pathogenic variant Pediatric Dermatology · 2024 · 2 citations
    15. Deimination in epidermal barrier and hair formation Philosophical transactions - Royal Society. Biological sciences · 2023 · 2 citations
    16. Pili trianguli et canaliculi as a phenotypic subtype in patients with central centrifugal cicatricial alopecia: A scanning electron microscopy study Journal of the American Academy of Dermatology · 2020 · 2 citations
    17. Ugreelig hår Tidsskrift for Den norske legeforening · 2022 · 1 citations
    18. Pathogenic variants affecting peptidyl arginine deiminase 3 and its major substrates underlie central centrifugal cicatricial alopecia Journal of Investigative Dermatology · 2025
    19. Pathogenic variants affecting peptidyl arginine deiminase 3 and its major substrates underlie central centrifugal cicatricial alopecia. PubMed · 2025
    20. 481 Pathogenic variants affecting peptidyl arginine deiminase 3 and its major substrates underlie central centrifugal cicatricial alopecia Journal of Investigative Dermatology · 2024
    21. Central centrifugal cicatricial alopecia: a subtype of lichen planopilaris in African descent? Portuguese Journal of Dermatology and Venereology · 2024
    22. Support for dermatological research in Sub‐Saharan Africa: insights from African hair and skin research programs International Journal of Dermatology · 2024
    23. This month in JAAD Case Reports: October 2023—Central centrifugal cicatricial alopecia in Black men Journal of the American Academy of Dermatology · 2023
    24. Uncombable hair syndrome due to maternal uniparental disomy of chromosome 1 American journal of medical genetics. Part A · 2022
    25. Uncombable hair syndrome and beyond Acta dermatovenerologica Alpina, Pannonica et Adriatica (Tiskana izd.) · 2022
    26. Central Centrifugal Cicatricial Alopecia (CCCA) CRC Press eBooks · 2021
    27. 부챗말 Glucopyranosyldiacylglycerol의 탈모방지 효능 생약학회지 · 2020
    28. Deciphering the pathogenesis of central centrifugal cicatricial alopecia 2019
    29. 284 Deciphering the pathogenesis of central centrifugal cicatricial alopecia Journal of Investigative Dermatology · 2019
    30. Hair regrowth in a patient with central centrifugal cicatricial alopecia after a 2-month trial of baricitinib JAAD Case Reports · 2023 · 2 citations