Ligand-Independent Vitamin D Receptor Actions Essential for Keratinocyte Homeostasis in the Skin

    January 2025 in “ International Journal of Molecular Sciences ”
    Satoko Kise, Shinichi Morita, Toshiyuki Sakaki … Kaori Yasuda
    Studysummary This study showed that vitamin D receptor gene-deficient rats exhibit hair loss and skin abnormalities due to differences in gene and protein expression patterns, while ligand-independent VDR action is crucial for normal hair cycle maintenance and skin formation.
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    Research cited in this study 14

    1. Characterization of Type II Rickets Model Rats to Reveal Functions of Vitamin D and Vitamin D Receptor Biomolecules · 2023
    2. Gene Therapy for Alopecia in Type II Rickets Model Rats Using Vitamin D Receptor-Expressing Adenovirus Vector Scientific Reports · 2023
    3. VDR Is an Essential Regulator of Hair Follicle Regression Through the Progression of Cell Death Life science alliance · 2023
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    5. Functional Analysis of Vitamin D Receptor Using Adenovirus Vector Journal of steroid biochemistry and molecular biology/˜The œJournal of steroid biochemistry and molecular biology · 2023
    6. Vitamin D And Calcium Regulation Of Epidermal Wound Healing The Journal of Steroid Biochemistry and Molecular Biology · 2015
    7. Vitamin D Receptor-Mediated Control of Soggy, Wise, and Hairless Gene Expression in Keratinocytes Journal of Endocrinology/Journal of endocrinology · 2013
    8. The Role of Vitamin D Receptor Mutations in the Development of Alopecia Molecular and Cellular Endocrinology · 2011
    9. Disruption of the Hedgehog Signaling Pathway Contributes to Hair Follicle Cycling Deficiency in VDR Knockout Mice Journal of Cellular Physiology · 2010
    10. Vitamin D and Human Health: Lessons from Vitamin D Receptor Null Mice Endocrine reviews · 2008
    11. The Vitamin D Receptor Is Required for Mouse Hair Cycle Progression but Not for Maintenance of the Epidermal Stem Cell Compartment ˜The œjournal of investigative dermatology/Journal of investigative dermatology · 2008
    12. Hairless Suppresses Vitamin D Receptor Transactivation in Human Keratinocytes Endocrinology · 2005
    13. Ligand-Independent Actions of the Vitamin D Receptor Maintain Hair Follicle Homeostasis Molecular Endocrinology · 2004
    14. Lack of the Vitamin D Receptor Is Associated with Reduced Epidermal Differentiation and Hair Follicle Growth ˜The œjournal of investigative dermatology/Journal of investigative dermatology · 2002