VDR Is an Essential Regulator of Hair Follicle Regression Through the Progression of Cell Death

    September 2023 in “ Life science alliance ”
    Yudai Joko, Yasutake Yamamoto, Shigeaki Kato … Shun Sawatsubashi
    Studysummary In this study, researchers observed that Vdr-knockout mice experience hair cycle arrest during the catagen stage, leading to alopecia, with persistent epithelial strands forming in the hair follicles, indicating Vitamin D receptor's role in regulating hair follicle regression and regeneration.
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    Research cited in this study 21

    1. Progenitor-Derived Endothelin Controls Dermal Sheath Contraction for Hair Follicle Regression Nature cell biology · 2023
    2. Morphogenesis, Growth Cycle, and Molecular Regulation of Hair Follicles Frontiers in Cell and Developmental Biology · 2022
    3. Immune Modulation of Hair Follicle Regeneration npj Regenerative Medicine · 2020
    4. Temporal Layering of Signaling Effectors Drives Chromatin Remodeling During Hair Follicle Stem Cell Lineage Progression Cell stem cell · 2018
    5. Epithelial-Mesenchymal Micro-Niches Govern Stem Cell Lineage Choices Cell · 2017
    6. Nongenomic Effects of 1α,25-Dihydroxyvitamin D3 on Cartilage Formation Deduced from Comparisons Between Cyp27b1 and Vdr Knockout Mice Biochemical and biophysical research communications · 2017
    7. Absence of Vitamin D Receptor-Mediated PPARγ Suppression Causes Alopecia in VDR-Null Mice The FASEB Journal · 2016
    8. Early Inductive Events in Ectodermal Appendage Morphogenesis Seminars in cell & developmental biology · 2014
    9. Adenovirus-Mediated Wnt10b Overexpression Induces Hair Follicle Regeneration Journal of Investigative Dermatology · 2012
    10. Paracrine TGF-β Signaling Counterbalances BMP-Mediated Repression in Hair Follicle Stem Cell Activation Cell stem cell · 2012
    11. The Role of Vitamin D Receptor Mutations in the Development of Alopecia Molecular and Cellular Endocrinology · 2011
    12. The Hair Follicle as a Dynamic Mini-Organ Current Biology · 2009
    13. Vitamin D Receptor Is Essential For Normal Keratinocyte Stem Cell Function Proceedings of the National Academy of Sciences · 2007
    14. Hair Follicle Expression of 1,25-Dihydroxyvitamin D3 Receptors During the Murine Hair Cycle British Journal of Dermatology · 2006
    15. The Hair Cycle Journal of Cell Science · 2006
    16. The Hair Cycle Journal of Cell Science · 2006
    17. Development and Progression of Alopecia in the Vitamin D Receptor Null Mouse Journal of cellular physiology · 2006
    18. Lack of the Vitamin D Receptor Is Associated with Reduced Epidermal Differentiation and Hair Follicle Growth ˜The œjournal of investigative dermatology/Journal of investigative dermatology · 2002
    19. Targeting Expression of the Human Vitamin D Receptor to the Keratinocytes of Vitamin D Receptor Null Mice Prevents Alopecia Endocrinology · 2001
    20. Targeting Expression of the Human Vitamin D Receptor to the Keratinocytes of Vitamin D Receptor Null Mice Prevents Alopecia Endocrinology · 2001
    21. The Role of the Hairless (Hr) Gene in the Regulation of Hair Follicle Catagen Transformation American Journal Of Pathology · 1999

    Related research 9

    1. VDR Is an Essential Regulator of Hair Follicle Regression Through the Progression of Cell Death Life science alliance · 2023
    2. Skin-On-A-Chip Strategies For Human Hair Follicle Regeneration Experimental Dermatology · 2022
    3. The Role of Vitamin D in Non-Scarring Alopecia International Journal of Molecular Sciences · 2017
    4. The Role of Vitamin D and Its Receptor in Hair Follicle Biology Elsevier eBooks · 2017
    5. Does D Matter? The Role of Vitamin D in Hair Disorders and Hair Follicle Cycling Dermatology Online Journal · 2010
    6. Role of the Vitamin D Receptor in Hair Follicle Biology The Journal of Steroid Biochemistry and Molecular Biology · 2007
    7. Hair Follicle Expression of 1,25-Dihydroxyvitamin D3 Receptors During the Murine Hair Cycle British Journal of Dermatology · 2006
    8. Development and Progression of Alopecia in the Vitamin D Receptor Null Mouse Journal of cellular physiology · 2006
    9. Towards a Molecular Understanding of Hair Loss and Its Treatment Trends in Molecular Medicine · 2001