Skin-On-A-Chip Strategies For Human Hair Follicle Regeneration

The review highlights the limitations of current hair follicle research models and the potential of in vitro organoids and organ-on-a-chip technologies for developing alopecia treatments. It emphasizes the importance of signaling molecules like EDA, FGF20, SHH, and Wnt in hair follicle development and growth. Advanced in vitro models, including 3D organoid cultures and bioprinting, have shown promise in mimicking hair follicle structures and inducing hair formation in mice. Despite progress, current models still fall short of replicating the hair follicle microenvironment, necessitating further optimization. The ultimate goal is to develop hair-on-a-chip technology for better hair follicle regeneration, hair transplantation, and drug development.