37 citations
,
June 2019 in “Stem cells” This study found that extracellular vesicles from stimulated human dermal fibroblasts enhanced hair follicle growth ex vivo by activating dermal papilla cells and involving the Norrin and β-catenin pathways.
58 citations
,
March 2019 in “Experimental Dermatology” This study suggests that exosomes derived from dermal papilla cells, especially those cultured in three dimensions, promote hair growth and regeneration by enhancing follicular cell activity.
25 citations
,
January 2019 in “British Journal of Dermatology” Low oxygen levels can make hair-growing cells better at growing hair through a process involving reactive oxygen species.
113 citations
,
November 2017 in “Scientific Reports” This study found that treatment with mesenchymal stem cell extracellular vesicles enhanced hair growth in mice and stimulated dermal papilla cell activity and growth factor production in vitro.
32 citations
,
April 2017 in “Scientific Reports” This study found that 5% activated platelet-rich plasma significantly improved cell proliferation and hair-inductive ability of dermal papilla cells in vitro, and promoted hair follicle formation in mice.
117 citations
,
March 2017 in “Nature Communications” This study shows that macrophage-induced TNF signaling can activate hair follicle stem cells and promote new hair follicle formation after wounding by regulating AKT/β-catenin pathways.
4 citations
,
January 2017 in “Annals of Dermatology” Tianeptine may help prevent hair loss by promoting hair growth and reducing cell death.
36 citations
,
January 2017 in “Stem Cells International” This study found that Wnt7a-containing conditioned medium from UC-MSCs can accelerate wound healing and promote hair follicle regeneration by enhancing specific cellular functions in the wound microenvironment.
26 citations
,
July 2016 in “PLOS ONE” This study demonstrated that β-catenin signaling in CD133+ dermal papilla cells enhances postnatal hair growth by accelerating the proliferation and differentiation of keratinocytes in the murine hair cycle.
9 citations
,
August 2015 in “Tissue Engineering and Regenerative Medicine” In this study, human dermal stem/progenitor cell-derived conditioned medium was found to promote hair regrowth in mice, possibly through effects on the Wnt/β-catenin pathway.
32 citations
,
June 2015 in “PLOS ONE” This study demonstrated that topical oleuropein induced hair growth in mice by activating the Wnt10b/β-catenin signaling pathway and increasing expression of several growth-related genes in skin tissue.
83 citations
,
January 2015 in “World Journal of Stem Cells” This review discusses current experimental approaches for regenerating human hair follicles using tissue engineering and isolated cells, but reports no successful strategies with adult cells yet found.
175 citations
,
December 2014 in “PLoS Biology” This study found that macrophages near hair follicles contribute to the activation of skin epithelial stem cells in mice, suggesting a novel role for macrophages in regulating hair growth.
61 citations
,
June 2014 in “Scientific Reports” This study found that overexpression of Wnt1a in bone marrow mesenchymal stem cells enhanced mouse hair follicle regeneration and promoted hair cycling.
17 citations
,
May 2014 in “Naunyn-Schmiedeberg's Archives of Pharmacology” In this study, 7-phloroeckol, derived from marine brown algae, was found to promote hair growth by increasing cell proliferation and hair shaft elongation in cultured human hair follicles.
179 citations
,
April 2012 in “Nature Communications” This study demonstrates the potential of using bioengineered follicles from adult tissue-derived stem cells for fully functional hair regeneration, illustrating possible applications in organ replacement therapy.
152 citations
,
April 2012 in “Recent Patents on Inflammation & Allergy Drug Discovery” This review describes minoxidil's hair regrowth mechanism and discusses dermatological applications, but reports no new clinical results, emphasizing the need for regular use and addressing allergic reactions.
88 citations
,
February 2011 in “Journal of Dermatological Science” This study found that topical minoxidil modestly extended the anagen phase in mice by activating β-catenin activity in dermal papilla cells.
314 citations
,
April 2010 in “Developmental Cell” This study found that in mice, inactivating beta-catenin in the dermal papilla reduces hair follicle progenitor proliferation and disrupts the hair cycle.
73 citations
,
March 2010 in “Food and Chemical Toxicology” This study found that Zizyphus jujuba essential oil enhanced hair growth in mice, with the 1% and 10% concentrations showing increased hair length compared to control.
63 citations
,
September 2009 in “Regenerative Medicine” This study developed a method for expanding human dermal papilla cells in vitro while maintaining their ability to induce hair growth, advancing the potential for follicular cell implantation as a treatment for hair loss.
127 citations
,
December 2007 in “Journal of Investigative Dermatology” This review examines regenerative hair waves and complex hair cycle domains in transgenic mice, highlighting how these dynamic processes contribute to skin regeneration and the physiological regulation of organs, but reports no new experimental results.
141 citations
,
November 2007 in “Journal of Investigative Dermatology” This study found that balding dermal papilla cells show premature senescence and altered expression of stress and DNA damage markers, suggesting sensitivity to environmental stress in androgenetic alopecia.
17 citations
,
January 2006 in “Veterinary Dermatology” This study found that topical melatonin and vigorous brushing did not affect hair regrowth in clipped Siberian Huskies, although lumbosacral hairs grew significantly shorter than lateral thigh hairs.
25 citations
,
June 2004 in “Journal of Investigative Dermatology” This study found that macrophage-stimulating protein (MSP) enhanced hair growth in both human hair follicles cultured in vitro and in mice through the promotion of anagen phase induction.
208 citations
,
December 2003 in “Journal of Investigative Dermatology” This study found that dermal papilla and peribulbar dermal sheath cup cells in mice can both induce hair follicle formation, suggesting they may have similar functional roles in hair growth.
520 citations
,
February 2001 in “Journal of Clinical Investigation” This study found that VEGF significantly enhances perifollicular vascularization during the hair growth phase, accelerating hair regrowth and increasing follicle and hair size, while its inhibition retards hair growth.
158 citations
,
November 1998 in “Cell” β-catenin affects hair growth and can lead to tumors, needing more research for better understanding.
90 citations
,
October 1996 in “Dermatologic Clinics” This study found that red ginseng oil may enhance hair growth and protect skin from UV damage in mouse models by promoting regenerative processes and reducing inflammation.
