TLDR Tianeptine may help prevent hair loss by promoting hair growth and reducing cell death.
The study explored the impact of tianeptine, an anti-depressant, on counteracting hair growth inhibition caused by dickkopf 1 (DKK-1) in cultured human hair follicles. DKK-1, known to be elevated in balding scalps, inhibited hair shaft elongation and increased apoptosis in follicular keratinocytes. Tianeptine treatment mitigated these effects, promoting hair shaft growth and reducing apoptosis. Additionally, tianeptine improved the viability of dermal papilla cells and increased levels of growth factors like IGF-1, HGF, VEGF, and KGF. These results indicated that tianeptine or its derivatives might be used to treat and prevent hair loss by influencing hair cycling.
22 citations
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December 2014 in “Naunyn-Schmiedeberg's Archives of Pharmacology” Baicalin helps hair grow by boosting certain cell activities and speeding up hair cycle in mice.
7 citations
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April 2013 in “Clinical and Experimental Dermatology” Tianeptine, an antidepressant, may prevent stress-induced hair loss in mice.
72 citations
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January 2012 in “Annals of Dermatology” IGF-I promotes hair growth by keeping hair follicles in the growth phase longer.
171 citations
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July 2007 in “Journal of Investigative Dermatology” A substance called DKK-1 increases in balding areas and causes hair cells to die when exposed to DHT.
375 citations
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February 2006 in “Journal of Cell Science” The document concludes that the hair cycle is a complex process involving growth, regression, and rest phases, regulated by various molecular signals.
277 citations
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June 2003 in “The journal of investigative dermatology. Symposium proceedings/The Journal of investigative dermatology symposium proceedings” Epithelial-mesenchymal interactions control hair growth cycles through specific molecular signals.
August 2014 in “Journal of clinical & experimental dermatology research” Platelet-released growth factors can treat hair loss by activating hair follicle stem cells, blocking certain pathways, and controlling inflammation and fibrosis.
36 citations
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June 2009 in “Nanomedicine” Fullerene nanomaterials help hair grow faster and increase hair follicles.
236 citations
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July 2001 in “Trends in Molecular Medicine” Future hair loss treatments should aim to extend hair growth, reactivate resting follicles, reverse shrinkage, and possibly create new follicles, with gene therapy showing promise.
