Baicalin, A Flavonoid, Affects The Activity Of Human Dermal Papilla Cells And Promotes Anagen Induction In Mice

In the 2014 study, researchers found that baicalin, a flavonoid, stimulated hair growth by activating the Wnt/β-catenin signaling pathway in human dermal papilla cells in a dose-dependent manner. Baicalin also increased the activity and mRNA expression of alkaline phosphatase, as well as the mRNA expression of growth factors such as IGF-1 and VEGF, which are associated with hair growth. In mice, topical application of baicalin induced a quicker transition from the resting phase to the growth phase of the hair cycle compared to a control treatment. The study concluded that baicalin has a positive effect on hair growth by enhancing the activity of dermal papilla cells.