Baicalin, A Flavonoid, Affects The Activity Of Human Dermal Papilla Cells And Promotes Anagen Induction In Mice

    December 2014 in “ Naunyn-Schmiedeberg's Archives of Pharmacology ”
    Sug Kyun Shin, Soon‐Sun Bak, Moon Kyu Kim, Young Kwan Sung, Jung Chul Kim
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    TLDR Baicalin helps hair grow by boosting certain cell activities and speeding up hair cycle in mice.
    In the 2014 study, researchers found that baicalin, a flavonoid, stimulated hair growth by activating the Wnt/β-catenin signaling pathway in human dermal papilla cells in a dose-dependent manner. Baicalin also increased the activity and mRNA expression of alkaline phosphatase, as well as the mRNA expression of growth factors such as IGF-1 and VEGF, which are associated with hair growth. In mice, topical application of baicalin induced a quicker transition from the resting phase to the growth phase of the hair cycle compared to a control treatment. The study concluded that baicalin has a positive effect on hair growth by enhancing the activity of dermal papilla cells.
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