Cardamonin-Loaded Liposomal Formulation for Improving Percutaneous Penetration and Follicular Delivery for Androgenetic Alopecia

    Zhenda Liu, Zhiyao He, Xinyi Ai, Teng Guo, Nianping Feng
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    TLDR A new liposomal formulation improves drug delivery and hair growth for treating hair loss without causing skin irritation.
    The study developed a Cardamonin-loaded liposomal formulation (CAR@Lip and CAR@Lip Gel) for treating Androgenic alopecia (AGA). This formulation improved the release of Cardamonin (CAR), promoted the growth and movement of human dermal papilla cells, and increased the uptake of CAR compared to the free drug. Both CAR@Lip and CAR@Lip Gel improved the transdermal performance of CAR and increased the drug's topical content in the hair follicle. Tests on mice showed that both formulations could promote hair growth and accelerate the transition of hair follicles to the growth stage by regulating the expression of IGF-1, VEGF, KGF, and TGF-β, and participating in SHH/Gli and Wnt/β-catenin pathways. The nanoformulations did not cause obvious skin irritation, indicating potential use in treating AGA.
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