Medicinal and Edible Plant Allium Macrostemon Bunge for the Treatment of Testosterone-Induced Androgenetic Alopecia in Mice

October 2023 in “ Journal of Ethnopharmacology ”

Ruiyang Gao, Zhilun Yu, Cheng Lv, Xiaolong Geng, Yijing Ren, Junyu Ren, Hao Wang, Fangbin Ai, Beibei Zhang, Bei Yue, Zhengtao Wang, Wei Dou

Allium macrostemon Bunge androgenetic alopecia human dermal papilla cells Wnt/β-catenin signaling pathway hair follicle formation growth factor secretion testosterone-induced AGA Hair Growth Index wild garlic AGA HDPCs Wnt signaling pathway

TLDR The wild garlic plant, Allium macrostemon Bunge, can promote hair growth and could potentially be used to treat hair loss.

The study investigated the effects of Allium macrostemon Bunge (AMB), a wild garlic plant, on androgenetic alopecia (AGA) in mice. The results showed that AMB promoted the proliferation and migration of human dermal papilla cells (HDPCs), and inhibited their apoptosis. AMB also activated the Wnt/β-catenin signaling pathway, which is involved in hair follicle formation and growth factor secretion. When this pathway was inhibited, the beneficial effects of AMB on HDPCs were abolished, suggesting that the Wnt/β-catenin signaling pathway is necessary for AMB's effects. In a testosterone-induced AGA mouse model, topical application of AMB promoted hair regeneration, with a higher Hair Growth Index, longer hair length, and greater hair weight compared to the control group. These findings suggest that AMB could be a potential treatment for AGA.

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