Hair Growth Stimulation Effect of Centipeda Minima Extract: Identification of Active Compounds and Anagen-Activating Signaling Pathways
July 2021
in “
Biomolecules
”
Centipeda minima extract CMX human hair follicle dermal papilla cells HFDPCs Wnt5a FZDR VEGF IGF-1 ERK JNK ß-catenin hair follicle development pharmacokinetic drug-likeness hair regeneration hair loss Centipeda minima hair follicle cells hair growth factors vascular endothelial growth factor insulin-like growth factor 1 extracellular signal-regulated kinase c-Jun N-terminal kinase beta-catenin hair growth drug properties
TLDR Centipeda minima extract helps hair grow by activating important growth signals and could be a promising hair loss treatment.
The study demonstrated that Centipeda minima extract (CMX) promotes hair growth by inducing the proliferation of human hair follicle dermal papilla cells (HFDPCs) and activating key signaling pathways involved in hair growth. CMX was found to upregulate the expression of genes and growth factors such as Wnt5a, FZDR, VEGF, and IGF-1, which are crucial for hair follicle development. The extract also increased the phosphorylation of ERK and JNK and the accumulation of ß-catenin in a dose-dependent manner. Four major compounds within CMX were identified, and the extract showed potential for oral administration due to favorable pharmacokinetic and drug-likeness profiles. The study, which included three independent experiments with statistical significance indicated by p-values less than 0.05, concluded that CMX could be a promising treatment for hair regeneration and combating hair loss.
