Pathophysiology, Conventional Treatments, And Evidence-Based Herbal Remedies Of Hair Loss With A Systematic Review Of Controlled Clinical Trials

    June 2025 in “ Naunyn-Schmiedeberg s Archives of Pharmacology ”
    Ahmed E. Allam, Riham A. El‐Shiekh, Ahmed M. El‐Dessouki, Noha M. Gamil, Nehal Mohamed Eisa, Mohamed Ayoub, Weam A M Khallil, Mohamed Farag, Madonna G Attallah, Mohamed S. Abd El Hafeez, Dina Abou-Hussein
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    TLDR Herbal remedies may help with hair loss but need more research.
    Hair loss, or alopecia, is influenced by genetic, hormonal, nutritional, and lifestyle factors, with treatments like minoxidil and finasteride having side effects and variable efficacy. Nutritional deficiencies, particularly in iron and vitamin D, are linked to alopecia, while stress and poor lifestyle choices exacerbate hair loss. Herbal remedies, such as rosemary and black seed oil, show promise but require more research to confirm efficacy. A systematic review of 16 randomized controlled trials (RCTs) evaluated phytotherapy's role in hair loss management, highlighting its potential as a safer alternative to conventional treatments. The review found varying levels of bias in the studies, emphasizing the need for larger, well-designed trials to confirm findings. Some studies showed herbal treatments comparable to minoxidil with fewer side effects, but methodological concerns remain. Overall, phytotherapy offers a promising avenue for hair loss treatment, but further research is needed to establish its efficacy and safety.
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