7 citations
,
February 2022 in “International Journal of Pharmaceutics” In a mouse model of androgenetic alopecia, this study found that a safflower oil body nanoparticle loaded with human fibroblast growth factor 10 significantly improved hair regeneration and reduced associated microinflammation without significant toxicity.
1 citations
,
January 2022 in “Dermatology Research and Practice” This study found that androgenetic alopecia negatively impacts the emotional and social well-being of Polish men, particularly younger individuals, with 66.7% reporting a significant effect on self-esteem.
3 citations
,
December 2021 in “Frontiers in Pharmacology” This study found that Ficus benghalensis leaf extracts reduced the activity of 5 α-reductase II and promoted hair growth in rabbits by elongating the hair follicle's anagen phase, suggesting potential for treating hair loss.
11 citations
,
November 2021 in “Clinical, Cosmetic and Investigational Dermatology” This study found that resveratrol promoted hair growth in mice and human hair follicles, suggesting its potential as a treatment for hair loss.
19 citations
,
May 2021 in “Clinical, Cosmetic and Investigational Dermatology” This review discusses the progress in research on topical formulations for treating alopecia, highlighting potential advantages of advanced formulation technologies but reporting no new clinical results.
23 citations
,
January 2021 in “Journal of Dermatological Science” This review describes the diagnosis and management challenges of telogen effluvium, a type of hair loss triggered by physiological stress, and summarizes current understanding of its mechanisms and treatments while recommending future research directions.
47 citations
,
December 2020 in “Journal of the European Academy of Dermatology and Venereology” This article reviews the classification, diagnosis, and management of hair disorders, emphasizing the role of trichoscopy and early diagnosis for effective treatment but reports no new clinical findings.
6 citations
,
November 2020 in “Journal of cosmetic dermatology” This study found that standardized para rubber seed oil may be a safe and effective bio-oil for stimulating hair growth and reducing hair loss, exhibiting comparable effects to minoxidil, dutasteride, and vitamin C in certain laboratory settings.
134 citations
,
July 2020 in “Experimental dermatology” This review discusses immune privilege in anagen hair follicles and its collapse in alopecia areata, emphasizing the importance of restoring this function for effective management and disease relapse prevention.
4 citations
,
May 2020 in “Dermatologic Therapy” In this study, a topical lotion containing Redensyl and Sepicontrol A5 demonstrated effectiveness for treating androgenetic alopecia over 24 weeks, with 73.1% of users seeing moderate improvement and notable increases in hair cycle ratios, alongside enhanced quality of life and satisfaction.
40 citations
,
May 2020 in “Cureus” This review discusses the causes, diagnosis, and treatment of telogen effluvium and reports no new clinical findings; the authors underscore the importance of identifying and eliminating causative factors.
29 citations
,
May 2020 in “npj Regenerative Medicine” This review discusses the role of the immune niche in hair follicle regeneration and its impact on different forms of alopecia, highlighting research gaps and potential therapeutic strategies.
24 citations
,
January 2020 in “International Journal of Molecular Sciences” This review discusses the potential benefits of flavonoid-containing botanicals, such as Panax ginseng, in reducing hair loss and promoting hair growth, but reports no new experimental results.
17 citations
,
January 2020 in “Skin appendage disorders” This review suggests that the Mediterranean diet, protein-rich diets, and soy may support hair health in nonscarring alopecias like androgenetic alopecia.
136 citations
,
May 2019 in “Cells” This review discusses the advancements in intraoperative stem cell therapies and highlights their potential to improve hair regrowth, but it reports no new clinical results.
45 citations
,
April 2019 in “International Immunology” This review discusses the mechanisms behind alopecia areata and primary cicatricial alopecia and reports no new clinical results, aiming to guide the development of targeted treatments.
134 citations
,
December 2018 in “Dermatology and Therapy” This review discusses the potential role of vitamins and minerals in managing non-scarring alopecia but reports no clinical results; the authors advocate for further controlled trials to explore these relationships.
23 citations
,
April 2018 in “Journal der Deutschen Dermatologischen Gesellschaft” This review discusses the classification and diagnosis of primary cicatricial alopecias and reports no new clinical results; it highlights the need for effective treatments owing to limited evidence of current therapies' efficacy.
11 citations
,
January 2018 in “DOAJ (DOAJ: Directory of Open Access Journals)” This case report observed that while a 4-year-old boy with vitamin D-dependent rickets type II showed biochemical and bone improvement after vitamin D and calcium treatment, his alopecia did not improve.
24 citations
,
January 2018 in “Indian Journal of Dermatology, Venereology and Leprology” This review discusses advances in molecular biology and genetics related to androgenetic alopecia and reports no new clinical results.
29 citations
,
December 2017 in “International Journal of Dermatology” This study found that vitamin D deficiency in patients with alopecia areata was associated with greater disease severity and longer duration, but not with disease pattern or vitamin D receptor expression.
32 citations
,
December 2017 in “International Journal of Molecular Sciences” This review suggests that decreased serum 25-hydroxyvitamin D levels may play a role in different types of non-scarring alopecia, but further studies are needed to explore vitamin D supplementation as a therapeutic option.
12 citations
,
November 2017 in “Archives of Dermatological Research” This study suggests that high consumption of raw vegetables and fresh herbs, which are part of the Mediterranean diet, may reduce the risk of androgenetic alopecia in genetically predisposed men.
27 citations
,
September 2017 in “Journal of Medicinal Food” In this study, researchers found that a polyphenolic extract from Annurca apples, high in procyanidin B2, increased hair growth, density, and keratin content in healthy subjects after 2 months of use, and stimulated keratin biosynthesis in vitro.
63 citations
,
May 2017 in “American Journal of Clinical Dermatology” This review found that patients with alopecia areata may have lower levels of vitamin D, zinc, and folate, but conflicting evidence precludes definitive clinical recommendations for micronutrient supplementation.
79 citations
,
January 2017 in “Dermatology practical & conceptual” This article addresses the need to screen for nutrient deficiencies in patients with hair loss but reports no new findings, noting that supplementation without deficiency may not be beneficial and could pose risks.
22 citations
,
January 2017 in “Skin appendage disorders” This research analyzed 72 primary scarring alopecia cases in a Barcelona hospital, finding that the majority involved women, with a lymphocytic infiltrate and subacute onset in many cases, leading to stable disease, while neutrophilic cases had more acute episodes.
69 citations
,
August 2016 in “PubMed” This article discusses the relationship between cortisol, stress, and hair follicle function and highlights oral supplementation with a specific proteoglycan as a promising treatment for stress-related hair growth disorders, but it does not present new clinical results.
18 citations
,
May 2016 in “Annals of Medicine” This paper reviews seven major systemic causes of hair loss and provides a clinical evaluation framework but reports no new experimental results.
71 citations
,
January 2016 in “International Journal of Trichology” This study found that 38% of women with hair loss had a biotin deficiency, suggesting oral biotin supplementation should be based on confirmed biotin deficiency rather than as a general treatment.
52 citations
,
July 2015 in “International Journal of Dermatology” This study found that patients with alopecia areata had significantly lower serum zinc levels, which correlated inversely with disease severity, duration, and resistance to therapies, suggesting zinc assessment as a marker of disease status.
18 citations
,
October 2014 in “Experimental Biology and Medicine” This study found that feeding mice high levels of dietary vitamin A increased WNT signaling, which activated hair follicle stem cells and may have accelerated alopecia areata progression.
19 citations
,
April 2014 in “Hormones” Hormones and genetics play key roles in male and female baldness, which can affect mental health and may be linked to other health issues.
39 citations
,
September 2013 in “Journal of Cosmetic Dermatology” This review summarizes causes and treatments of androgenetic alopecia with a focus on herbs as potential alternatives, but reports no new results and suggests more research is needed to validate these options.
48 citations
,
May 2013 in “Canadian Medical Association Journal” This article discusses common causes of hair loss, specifically androgenetic alopecia and alopecia areata, but reports no new clinical findings.
73 citations
,
January 2013 in “Annals of Dermatology” This study observed that patients with various types of hair loss had significantly lower serum zinc levels compared to healthy controls, suggesting zinc disturbance may play a role in the condition.
98 citations
,
October 2012 in “Dermatologic Clinics” This article reviews the impact of nutritional deficiencies on hair health, detailing how they can cause structural abnormalities, pigmentation changes, or hair loss; it presents no new clinical findings.
54 citations
,
September 2012 in “The journal of investigative dermatology/Journal of investigative dermatology” This study suggests that vitamin A influences the immune response and hair cycle, affecting the progression of alopecia areata in mouse models.
54 citations
,
September 2012 in “Dermatologic Clinics” This review discusses possible medication-induced hair loss and the need to exclude other confounding factors like stress and illness; it reports no new clinical findings and emphasizes careful assessment before attributing hair loss to medications.
49 citations
,
April 2012 in “Phytotherapy Research” This study found that topical Rosmarinus officinalis leaf extract improved hair regrowth in mice and inhibited androgen-associated mechanisms involved in hair loss.
50 citations
,
September 2011 in “Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids” This review examines the role of retinoic acid synthesis in hair follicles and sebaceous glands, focusing on its localization and function during normal and disease states, but reports no new results.
39 citations
,
October 2010 in “Journal of The American Academy of Dermatology” This study reported that alopecia occurred in 2.5% of patients with mycosis fungoides or Sézary syndrome, with some cases resembling alopecia areata and others associated with specific skin lesions.
101 citations
,
August 2010 in “PLoS ONE” In this mouse study, severe selenoprotein deficiency in epidermal cells was linked to skin abnormalities, disrupted hair follicle development, and progressive alopecia, highlighting the role of selenoproteins in skin and hair health.
70 citations
,
June 2010 in “Clinics in Dermatology” This review discusses how changes in hair and skin may indicate underlying vitamin deficiencies and emphasizes the need to identify populations at risk for these deficiencies; it reports no new results.
382 citations
,
February 2010 in “Archives of Internal Medicine” This study identified that high concentrations of selenium in a liquid dietary supplement caused a widespread outbreak of poisoning, revealing the importance of stricter manufacturing standards.
36 citations
,
January 2010 in “Journal of Pediatric Endocrinology and Metabolism” This study identified a novel nonsense mutation in the VDR gene in two patients with hereditary vitamin D resistant rickets and alopecia, leading to resistance to 1,25-dihydroxyvitamin D3.
36 citations
,
August 2009 in “PubMed” This article discusses different types of hair loss, their potential causes, and treatment options, but it reports no new clinical findings; the authors emphasize the importance of considering the emotional impact on patients.
70 citations
,
January 2009 in “Indian Journal of Dermatology, Venereology and Leprology” This article reviews the characteristics, diagnosis, and management of different types of diffuse alopecia in women and provides no original research findings.
20 citations
,
July 2008 in “Dermatologic Therapy” This review discusses various nonfollicular scalp conditions causing secondary scarring or permanent alopecia and highlights the importance of specific diagnoses and treatments but reports no new results.
207 citations
,
April 2006 in “Journal of The American Academy of Dermatology” This review discusses the complexities of diagnosing and treating iron deficiency related to nutritional anemia and hair loss, concluding that routine screening and supplementation for hair loss are not yet supported by sufficient evidence.
32 citations
,
January 2006 in “Liver transplantation” This case report describes a 60-year-old male with vitamin A toxicity leading to severe liver disease and symptoms that resolved following liver transplantation, suggesting transplantation as a treatment option for noncirrhotic portal hypertension when symptoms do not improve after stopping vitamin A.
163 citations
,
November 2003 in “Journal of Investigative Dermatology” This study found that women with androgenetic alopecia or alopecia areata have significantly lower serum ferritin levels than those without hair loss, suggesting a potential link between these types of alopecia and decreased iron stores.
51 citations
,
January 2003 in “Hormone Research in Paediatrics” This review discusses hormonal influences on hair growth and suggests that understanding hormone-gene interactions may improve treatment of hirsutism and alopecia, but reports no new clinical findings.
239 citations
,
July 2002 in “Clinical and Experimental Dermatology” This review explores the role of nutritional factors in hair loss, noting that iron and l-lysine supplementation may benefit some individuals, while excessive supplements can lead to hair shedding.
115 citations
,
December 2001 in “Endocrinology” This study found that restoring vitamin D receptor expression specifically in the keratinocytes of VDR null mice prevented alopecia and enhanced hair follicle response during anagen initiation.
236 citations
,
July 2001 in “Trends in Molecular Medicine” This review discusses common hair loss conditions and explores how advancements in hair follicle biology might lead to more effective treatments but reports no new results.