Ficus Benghalensis as Potential Inhibitor of 5α-Reductase for Hair Growth Promotion: In Vitro, In Silico, and In Vivo Evaluation

December 2021 in “ Frontiers in Pharmacology ”

Jawaria Iltaf, Sobia Noreen, Muhammad Fayyaz ur Rehman, Shazia Akram Ghumman, Fozia Batool, Muhammad Mehdi, Sara Hasan, Bushra Ijaz, Muhammad Safwan Akram, Haider Butt

Ficus benghalensis 5α-reductase hair growth in vitro in silico in vivo androgenic alopecia bioactive compounds molecular docking 5α-reductase II hair regrowth skin irritation FBLEs hair loss hair growth promotion

TLDR Ficus benghalensis leaf extracts can effectively promote hair growth and inhibit hair loss.

The study evaluates Ficus benghalensis leaf extracts (FBLEs) for their potential to inhibit 5α-reductase and promote hair growth using in vitro, in silico, and in vivo methods. The extracts showed significant inhibition of the enzyme, which is involved in androgenic alopecia, and promoted hair regrowth in rabbits without causing skin irritation. Molecular docking confirmed strong binding interactions of the extract's bioactive compounds with the enzyme. The study concludes that FBLEs can effectively stimulate hair growth and inhibit 5α-reductase II activity, making them promising candidates for natural hair growth treatments.

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