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Glossary in silico

experiments conducted using computer simulations or computational models

"In silico" refers to experiments or research conducted via computer simulations or computational models, rather than in a laboratory (in vitro) or within a living organism (in vivo). For example, in the context of hair and alopecia research, scientists might use in silico methods to predict how certain genes or drugs could affect hair growth by analyzing large datasets and running simulations, which can save time and resources compared to traditional experimental methods.

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Research

5 / 1000+ results

research Manganese-Doped Calcium Silicate Nanowire Composite Hydrogels for Melanoma Treatment and Wound Healing

44 citations , January 2021 in “Research”

This study explored the use of manganese-doped calcium silicate nanowire-incorporated alginate hydrogels (MCSA hydrogels) for treating melanoma and promoting wound healing, finding that these hydrogels effectively ablate melanoma under near-infrared irradiation and enhance vascular endothelial cell activity for tissue regeneration.

research In silico prediction of prostaglandin D2 synthase inhibitors from herbal constituents for the treatment of hair loss

30 citations , October 2015 in “Journal of Ethnopharmacology”

This study identified several compounds from traditional Chinese medicines that may inhibit prostaglandin D2 synthase, potentially providing promising candidates for treating androgenic alopecia with minimal adverse skin reactions.

research Drug repositioning using in silico compound profiling

24 citations , December 2009 in “Future Medicinal Chemistry”

This study identified new potential targets and indications for several marketed drugs using in silico profiling, suggesting opportunities for drug repositioning.

research Silicon-Related Syndrome in Dialysis Patients

21 citations , January 1997 in “Nephron”

In this study, two dialysis patients with high plasma silicon levels exhibited symptoms like painful skin eruptions and unusual hair growth, suggesting silicon may influence calcium metabolism similarly to aluminum.

research In vivo penetration of bare and lipid-coated silica nanoparticles across the human stratum corneum

16 citations , August 2014 in “Colloids and surfaces. B, Biointerfaces”

This study found that hydrophobic lipid-coated silica nanoparticles penetrated deeper into human stratum corneum compared to their hydrophilic counterparts, highlighting the influence of surface polarity on skin penetration.

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Community Join

5 / 105 results

community Do silicone based shampoos/conditioners affect the absorption of topicald?

5 upvotes 2 years ago

Silicone-based shampoos and conditioners may leave a layer on the scalp that could affect the absorption of topical hair loss treatments like Fluridil. The user is considering switching to silicone products to manage frizzy hair but is concerned about this potential issue.

community Do those silicone scalp massagers help or hurt hair?

4 upvotes 2 years ago

Using a silicone scalp massager may cause hair shedding, but it could also stimulate blood flow and help with scalp conditions. Finasteride and minoxidil are used to manage hair loss, with mixed results on regrowth and maintenance.

community What Hinders the Absorption of Minoxidil?

in Minoxidil 1 upvotes 1 year ago

Silicone and dimethicone in shampoos may hinder Minoxidil absorption, while Tretinoin and microneedling can enhance its efficacy. Users discuss applying Tretinoin before Minoxidil, waiting for it to dry first.

community Scalp massagers really do work.

4 upvotes 2 years ago

Silicone scalp massagers are claimed to slow or reverse hair loss and improve hair regrowth, with users reporting reduced shedding and scalp tension. Some users also mention using them alongside treatments like minoxidil and finasteride for better results.

community VT Reedle Shot for hair growth?

1 upvotes 11 months ago

The VT Reedle Shot, a skincare product using silica spicules, is discussed as a potential at-home alternative to microneedling for hair regrowth. It is suggested that different intensities may aid in hairline regrowth.

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