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Glossaryin silico

experiments conducted using computer simulations or computational models

"In silico" refers to experiments or research conducted via computer simulations or computational models, rather than in a laboratory (in vitro) or within a living organism (in vivo). For example, in the context of hair and alopecia research, scientists might use in silico methods to predict how certain genes or drugs could affect hair growth by analyzing large datasets and running simulations, which can save time and resources compared to traditional experimental methods.

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research In Silico Prediction of Prostaglandin D2 Synthase Inhibitors from Herbal Constituents for the Treatment of Hair Loss

30 citations, October 2015 in “Journal of Ethnopharmacology”

Herbal compounds like ricinoleic acid, quercetin-3-O-rutinoside, and hinokiflavone may be safe and effective for treating hair loss.

In Silico Analysis of Gene Expression Data from Bald Frontal and Haired Occipital Scalp to Identify Candidate Genes in Male Androgenetic Alopecia

research In Silico Analysis of Gene Expression Data from Bald Frontal and Haired Occipital Scalp to Identify Candidate Genes in Male Androgenetic Alopecia

6 citations, September 2019 in “Archives of Dermatological Research”

Found 32 genes linked to male baldness, affecting hair growth and stress-related pathways.

GC-MS Profiling and In Silico Prediction of MAPK Receptor Activation by Fatty Acids of Watercress Oil for Hair Growth Marketed in Saudi Arabia

research GC-MS Profiling and In Silico Prediction of MAPK Receptor Activation by Fatty Acids of Watercress Oil for Hair Growth Marketed in Saudi Arabia

5 citations, January 2021 in “Journal of Saudi Chemical Society”

Watercress oil may promote hair growth by activating specific receptors.

research In Silico Analysis of the Age-Dependent Evolution of the Transcriptome of Mouse Skin Stem Cells

4 citations, January 2020 in “Cells”

The research found that the gene activity in mouse skin stem cells changes significantly as they age.

research Ficus Benghalensis as Potential Inhibitor of 5α-Reductase for Hair Growth Promotion: In Vitro, In Silico, and In Vivo Evaluation

3 citations, December 2021 in “Frontiers in Pharmacology”

Ficus benghalensis leaf extracts can effectively promote hair growth and inhibit hair loss.

research In Silico Prediction of Metabolites in Petroselinum Crispum for Inhibiting Androgen Receptor as Treatment for Alopecia

3 citations, March 2022 in “Research journal of pharmacy and technology”

Parsley contains compounds that might be good for treating hair loss.

research In-Silico Cardiac Aging Regulatory Model Including MicroRNA Post-Transcriptional Regulation

3 citations, June 2017 in “Methods”

Researchers created a model to understand heart aging, highlighting the role of microRNAs and identifying key genes and pathways involved.

research In Silico Structural Prediction of Human Steroid 5α-Reductase Type II

3 citations, March 2016 in “Medicinal Chemistry Research”

Scientists found out the structure of a human enzyme linked to prostate cancer and hair loss, which could help in designing drugs.

The Identification of Molecular Mechanisms from Bioactive Compounds in Sansevieria Trifasciata Plant as Anti-Alopecia: In-Silico Approach

research The Identification of Molecular Mechanisms from Bioactive Compounds in Sansevieria Trifasciata Plant as Anti-Alopecia: In-Silico Approach

2 citations, January 2022 in “Rasayan journal of Chemistry”

Compounds from the Sansevieria trifasciata plant might be effective for treating hair loss.

research In Silico Screening of Moroccan Medicinal Plants with the Ability to Directly Inhibit the Novel Coronavirus, SARS-CoV-2

2 citations, July 2020 in “Research Square (Research Square)”

Some Moroccan medicinal plants may contain compounds that can inhibit the virus causing COVID-19.

research Isolation and Identification of Hair Growth Potential Fraction from Active Plant Extract of Blumea Eriantha DC Grown in Western Ghat of India: In Silico Study

1 citations, April 2022 in “Journal of Ayurveda and integrative medicine”

Blumea eriantha DC extract shows strong potential for promoting hair growth.

Anti-Alopecia Activity of Alkaloids from Noni Fruit Against Dihydrotestosterone-Induced Male Rabbits and Its Molecular Mechanism: In Vivo and In Silico Studies

research Anti-Alopecia Activity of Alkaloids from Noni Fruit Against Dihydrotestosterone-Induced Male Rabbits and Its Molecular Mechanism: In Vivo and In Silico Studies

1 citations, December 2022 in “Pharmaceuticals”

Noni fruit extract, specifically the FEA-3 sub-fraction, can increase hair growth and reduce baldness in male rabbits, potentially acting like common hair loss treatments.

research In Silico Modelling of Transdermal Delivery of Macromolecule Drugs Assisted by a Skin Stretching Hypobaric Device

1 citations, November 2022 in “Pharmaceutical research”

The simulation showed that hypobaric pressure improves drug delivery through the skin, but stretching alone doesn't fully explain the increase.

research In Silico Screening of Effective Inhibitor of 5α-Reductase Type 1 for Androgenic Alopecia Treatment

1 citations, December 2021 in “Natural Product Research”

β-sitosterol and brassicasterol may help treat hair loss.

In Silico Analysis of Berberine as a Potential Therapeutic Approach for Various Signaling Pathways Linked to Androgenetic Alopecia

research In Silico Analysis of Berberine as a Potential Therapeutic Approach for Various Signaling Pathways Linked to Androgenetic Alopecia

July 2024 in “Recent Advances in Inflammation & Allergy Drug Discovery”

Berberine may be a safe and effective treatment for male pattern baldness.

research In Silico Study on the Contribution of the Follicular Route to Dermal Permeability of Small Molecules

February 2024 in “Pharmaceutical research”

Hair follicles affect how well small molecules can pass through the skin, and this varies depending on the molecule's features.

research In Silico Characterization and Analysis of Clinically Significant Variants of Lipase-H (LIPH Gene) Protein Associated with Hypotrichosis

May 2023 in “Pharmaceuticals”

Three specific mutations in the LIPH gene can cause hair loss by damaging the protein's structure and function.

research In-Silico Studies in Herbal Drugs: A Review

April 2018 in “Journal of Ayurvedic and herbal medicine”

Computational methods can speed up and improve the development and safety of herbal drugs.

In-Silico Study of Bioactive Compounds of Natural Materials as a JAK-Signal Transducer and Activator of Transcription Inhibitor for Anti-Alopecia

research In-Silico Study of Bioactive Compounds of Natural Materials as a JAK-Signal Transducer and Activator of Transcription Inhibitor for Anti-Alopecia

November 2017 in “Asian journal of pharmaceutical and clinical research”

Three compounds from Dadap leaves may help treat hair loss.

research In Silico Study of 12 Phytosterol Compounds in Moringa (Moringa Oleifera Lamk.) Seed Oil on 5α-Reductase Enzyme Inhibition Activity as Anti-Alopecia

November 2022 in “International Journal of Applied Pharmaceutics”

Ergostadienol from Moringa seed oil may help prevent hair loss.

Stability Study of Finasteride: Stability-Indicating LC Method, In Silico and LC-ESI-MS Analysis of Major Degradation Product, and an In Vitro Biological Safety Study

research Stability Study of Finasteride: Stability-Indicating LC Method, In Silico and LC-ESI-MS Analysis of Major Degradation Product, and an In Vitro Biological Safety Study

April 2018 in “Journal of Chromatographic Science”

Finasteride's stability and safety confirmed through precise analytical methods.

research Identification of Beta-Sitosterol and Stigmasterol as Possible Inhibitors of 5 Alpha-Reductase 1: An In-Silico Study

3 citations, January 2022 in “Precision medicine and clinical omics”

Beta-sitosterol and stigmasterol might help prevent hair loss by blocking a specific enzyme.

In Vitro and In Silico Evaluation of Toxicological and Anti-Proliferative Activity in Phytochemical Compounds of Several Solvent Extracts from Zaleya Pentandra L

research In Vitro and In Silico Evaluation of Toxicological and Anti-Proliferative Activity in Phytochemical Compounds of Several Solvent Extracts from Zaleya Pentandra L

March 2024 in “Journal of Pharmaceutical and Sciences”

Zaleya pentandra extracts, especially acetone, may be useful for new medicines and food industry applications.

research Bioprospecting of Potential Inhibitors of 5alpha Reductase 2 from Relevant Ethno-Pharmacological Plants via In Silico Techniques

May 2024 in “Scientific African”

Three natural compounds from Ghanaian plants may help treat BPH and alopecia.

research Antialopecia Activity Exploration by In-Silico Analysis of Bioactive Compounds from Sansevieria Trifasciata Prain Leaves Through 5α-Reductase Inhibition

January 2023 in “Rasayan journal of chemistry/Rasayan journal of Chemistry”

Methyl pyropheophorbide A from Sansevieria trifasciata leaves may help treat hair loss.

In Vivo and In Silico Evaluation of the Ameliorative Effect of Hesperidin on Finasteride-Induced Testicular Oxidative Stress in Wistar Rats

research In Vivo and In Silico Evaluation of the Ameliorative Effect of Hesperidin on Finasteride-Induced Testicular Oxidative Stress in Wistar Rats

4 citations, October 2020 in “Toxicology Mechanisms and Methods”

Hesperidin protects rat testicles from finasteride damage and improves sperm health.

research The Polycystic Ovary Syndrome Evolutionary Paradox: A Genome-Wide Association Studies-Based, In Silico, Evolutionary Explanation

47 citations, August 2014 in “The Journal of Clinical Endocrinology and Metabolism”

The research suggests that the global distribution of PCOS is likely due to historical human migration and that genes affecting PCOS may have different impacts on males and females.

The Possible Implication of the S250C Variant of the Autoimmune Regulator Protein in a Patient with Autoimmunity and Immunodeficiency: In Silico Analysis Suggests a Molecular Pathogenic Mechanism for the Variant

research The Possible Implication of the S250C Variant of the Autoimmune Regulator Protein in a Patient with Autoimmunity and Immunodeficiency: In Silico Analysis Suggests a Molecular Pathogenic Mechanism for the Variant

11 citations, July 2014 in “Gene”

The S250C variant in a gene may cause autoimmunity and immunodeficiency by impairing protein function.

research Discovering the Potential of Natural Remedies in Post COVID-19 Complications Based on In Silico Techniques

June 2022 in “Organic communications”

Natural compounds, especially Withaferin-A, may help treat post-COVID-19 complications, but some may have side effects.

research Characterization of Plant-Based Biotin from SesZenBio and In Silico Studies to Prove Its Potential in Hair Care

May 2022 in “International Journal of Biochemistry Research and Review”

Plant-based biotin from SesZenBioTM could be twice as effective as synthetic biotin for hair care.