In Silico Study on the Contribution of the Follicular Route to Dermal Permeability of Small Molecules

The in silico study explored how the hair follicle affects the dermal permeability of small molecules, focusing on the impact of properties like lipophilicity, molecular weight, and protein binding. The findings suggest that the follicular route's contribution to dermal permeation varies significantly based on the substance's characteristics within the follicle and the permeant itself. The study concludes that understanding the substance within the follicle is crucial for accurate interpretation of experimental data on dermal permeation, as the difference between in vivo and in vitro conditions can alter the follicular route's role, complicating the analysis of such data.