Permeation of Topically Applied Magnesium Ions Through Human Skin Is Facilitated by Hair Follicles

June 2016 in “ Magnesium research ”

Navin Chandrakanth Chandrasekaran, Washington Y. Sanchez, Yousuf Mohammed, Jeffrey E. Grice, Michael S. Roberts, Ross Barnard

magnesium ions stratum corneum hair follicles MgCl₂ solution magnesium skin barrier hair pores

TLDR Hair follicles help magnesium get through the skin more effectively.

The study from June 2016 found that magnesium ions can penetrate through the human stratum corneum and that hair follicles significantly enhance this permeation. A novel method was used to plug hair follicles, which showed that when follicles were blocked, magnesium penetration was significantly reduced. The research used a 1.9 M MgCl₂ solution and demonstrated a 40% increase in magnesium ion penetration over 15 minutes in skin sections with unplugged follicles. The findings indicate that while the stratum corneum offers resistance to magnesium ion penetration, the presence of hair follicles facilitates the process in a time- and concentration-dependent manner.

View this study on jle.com →

Discuss this study in the Community →

Related Community Posts Join

6 / 182 results

community Has anyone used Magnesium L-Threonate ?

74 upvotes 5 years ago

Magnesium L-Threonate may help treat balding by reducing DKK-1 expression without affecting DHT. Users discuss its potential effectiveness and application methods, with some considering trying it topically.

community Does taking magnesium have any effect on balding or regrowth?

in Research/Science 6 upvotes 4 years ago

The user has been using Minoxidil, finasteride, and microneedling for over a year but recently experienced more hair thinning and receding. They started taking magnesium supplements a month ago and are questioning if it is related to the worsening hair condition.

community Starting my journey taking fin 3 days a week. Minoxidil once daily. Pumpkin seed oil, biotin, zinc, and magnesium supplements daily. Strict no alcohol and no high sugar diet with regular exercise. Will post updates.

in Progress Pictures 17 upvotes 3 years ago

A user is starting a hair loss treatment regimen with finasteride three times a week, minoxidil once daily, and daily supplements of pumpkin seed oil, biotin, zinc, and magnesium. They are also following a strict no alcohol, no high sugar diet, and regular exercise, and plan to post updates.

community 5 month results on natural protocol, i made a post after 3 mont of treatment wich you can find in my profile. I used different massages(detumescence therapy, wooden brush, tom hagerty exercises)vitamins(d3,fish oil, biotin,msm, magnesium) drank green tea and ate pumpkin seeds( reduces dht)

in Is this regrowth? 146 upvotes 1 year ago

The user "Zealousideal-Pack340" shared their 5-month results on a natural hair loss treatment protocol, which included massages, vitamins, green tea, and pumpkin seeds. Some users suggested using medications like finasteride and minoxidil for better results, while others criticized the effectiveness of natural remedies. Overall, there was no clear consensus on the progress of the user's hair regrowth.

community Vitamin C and hair growth PH levels

in Product 31 upvotes 2 years ago

The conversation is about using vitamin C and Magnesium L-Threonate for hair growth by reducing DHT binding to dermal papilla cells. The original post about vitamin C's pH levels and sebum control was possibly removed by a moderator.

community Supplements for hair growth (Alcoholics, Smokers; and Gym Goers)

in Treatment 6 upvotes 5 months ago

A user shared their experience with hair loss and recommended supplements like magnesium, vitamin D, vitamin C, zinc, iron, and protein, along with using a dermaroller. They noted benefits such as accelerated fat loss, muscle growth, better digestion, increased testosterone, and improved hair and skin quality.

Similar Research

5 / 771 results

research Hair Follicle-Targeted Delivery of Azelaic Acid Micro/Nanocrystals Promotes the Treatment of Acne Vulgaris

June 2024 in “International journal of nanomedicine”

Azelaic acid micro/nanocrystals, especially with ultrasound and salicylic acid, greatly improve acne treatment.

research Curcumin-Zinc Framework Encapsulated Microneedle Patch for Promoting Hair Growth

January 2023 in “Theranostics”

A patch with curcumin-zinc can improve hair growth and health by delivering beneficial particles to the skin, increasing hair follicles, and reversing effects of a hair loss hormone.

A Topical Scalp Serum Containing Adenosine, Magnesium Sulfate, Vitamin C Glucoside, and Pre- and Probiotic Fractions Reduces Discomfort and Associated Symptoms of Sensitive Scalp

research A Topical Scalp Serum Containing Adenosine, Magnesium Sulfate, Vitamin C Glucoside, and Pre- and Probiotic Fractions Reduces Discomfort and Associated Symptoms of Sensitive Scalp

November 2023 in “Dermatologic therapy”

The scalp serum reduced scalp discomfort and symptoms without affecting skin moisture loss.

research Advances in Chitosan-Based Nanoparticles for Drug Delivery

96 citations, September 2021 in “International Journal of Molecular Sciences”

Chitosan, a natural substance, can be used to create tiny particles that effectively deliver various types of drugs, but more work is needed to improve stability and control of drug release.

research In Silico Study on the Contribution of the Follicular Route to Dermal Permeability of Small Molecules

February 2024 in “Pharmaceutical research”

Hair follicles affect how well small molecules can pass through the skin, and this varies depending on the molecule's features.