Curcumin-Zinc Framework Encapsulated Microneedle Patch for Promoting Hair Growth

January 2023 in “ Theranostics ”

Yating Yang, Pei Wang, Yan Gong, Ziyou Yu, Yuci Gan, Peizhe Li, Wei Liu, Xiansong Wang

curcumin-zinc framework ZnMOF microneedle patch ZnMOF-MN dermal papilla cells apoptosis zinc deficiency dihydrotestosterone DHT hair follicles androgenic alopecia curcumin zinc microneedle hair loss hair regrowth

TLDR A patch with curcumin-zinc can improve hair growth and health by delivering beneficial particles to the skin, increasing hair follicles, and reversing effects of a hair loss hormone.

The study investigated a curcumin-zinc framework (ZnMOF) encapsulated microneedle patch (ZnMOF-MN) as a potential treatment for hair loss. The ZnMOF-MN patch was found to effectively deliver bioactive ZnMOF particles to the skin, improving the viability of dermal papilla cells and inhibiting apoptosis induced by zinc deficiency. It also reversed the inhibitory effects of dihydrotestosterone (DHT), a hormone linked to hair loss. In vivo, the treatment accelerated wound healing, increased hair follicles, and improved hair regrowth in androgenic alopecia animal models. The study concluded that the ZnMOF-MN treatment is a comprehensive solution for promoting hair growth under various clinical conditions.

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Research cited in this study

14 / 14 results

research Minoxidil-Loaded Hyaluronic Acid Dissolving Microneedles to Alleviate Hair Loss in an Alopecia Animal Model

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research The Role of Oxidative Stress in Early-Onset Androgenetic Alopecia

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research Prostaglandin D2 Inhibits Hair Growth and Is Elevated in Bald Scalp of Men with Androgenetic Alopecia

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PGD2 stops hair growth and is higher in bald men with AGA.

Curcumin-Zinc Framework Encapsulated Microneedle Patch for Promoting Hair Growth

Research cited in this study

research Minoxidil-Loaded Hyaluronic Acid Dissolving Microneedles to Alleviate Hair Loss in an Alopecia Animal Model

research Ceria Nanozyme-Integrated Microneedles Reshape the Perifollicular Microenvironment for Androgenetic Alopecia Treatment

research Dihydrotestosterone-Induced Hair Regrowth Inhibition by Activating Androgen Receptor in C57BL6 Mice Simulates Androgenetic Alopecia

research Microneedling: A Novel Therapeutic Approach for Androgenetic Alopecia, A Review of Literature

research Hormonal Effects on Hair Follicles

research Dihydrotestosterone Regulates Hair Growth Through the Wnt/β-Catenin Pathway in C57BL/6 Mice and In Vitro Organ Culture

research The Role of Vitamins and Minerals in Hair Loss: A Review

research Androgens and Androgen Receptor Action in Skin and Hair Follicles

research Androgens Modify Wnt Agonists/Antagonists Expression Balance in Dermal Papilla Cells Preventing Hair Follicle Stem Cell Differentiation in Androgenetic Alopecia

research The Role of Oxidative Stress in Early-Onset Androgenetic Alopecia

research Vitamin and Mineral Deficiencies in Patients With Telogen Effluvium: A Retrospective Cross-Sectional Study

research Oxidative Stress in Androgenetic Alopecia

research Analysis of Serum Zinc and Copper Concentrations in Hair Loss

research Prostaglandin D2 Inhibits Hair Growth and Is Elevated in Bald Scalp of Men with Androgenetic Alopecia

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