Metallic Elements Combine With Herbal Compounds in Microneedles to Promote Wound Healing: A Review

    November 2023 in “ Frontiers in Bioengineering and Biotechnology ”
    Xiao Tang, Li Li, Gehang You, Xinyi Li, Jian Kang
    TLDR Combining metals and herbs in microneedles can improve wound healing.
    The review examines the synergistic effects of combining metallic elements with herbal compounds in microneedles (MNs) to enhance wound healing. It highlights the antimicrobial properties of metals like zinc, silver, magnesium, and copper, which, when incorporated into MNs, improve therapeutic efficiency and reduce toxicity. Herbal compounds complement these metals by promoting cell proliferation and reducing inflammation. The review discusses various types of MNs, such as solid, coating, hollow, dissolving, and hydrogel, each offering specific advantages in drug delivery and wound treatment. The integration of MNs with other dressings, like hydrogels, is explored to provide a supportive environment for cell migration and pathogen isolation. Despite challenges like metal toxicity and lack of target specificity, the review suggests that advancements in MN technology could lead to more effective wound healing treatments.
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