The Trilogy of Skin Regeneration via Metal-Organic Frameworks Nanomedicine: Precision Management of Refractory Wounds, Pathological Scarring, and Hair Follicle Reactivation

    August 2025 in “ International Journal of Nanomedicine ”
    Lv Xiong, Chun Xiang, Yan Zheng, Xu-Ling Lv, Wan-Xuan Zhou
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    TLDR Metal-organic frameworks can help heal wounds, reduce scars, and promote hair growth, but more research is needed.
    The document reviews the potential of metal-organic frameworks (MOFs) in skin regeneration, particularly for diabetic wounds, pathological scars, and hair follicle reactivation. MOFs, especially zinc-based ones, offer antibacterial, anti-inflammatory, and regenerative benefits, making them suitable for advanced wound dressings. They enable precise drug delivery and enhance wound healing by modulating the wound environment. MOFs also show promise in hair regeneration by facilitating deep transdermal delivery and promoting hair growth. Despite their potential, challenges such as biocompatibility, stability, and clinical translation remain, necessitating further research and optimization.
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