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Glossary Transdermal Delivery

method of administering drugs through the skin for absorption

Transdermal Delivery, also known as Transdermal Drug Delivery, is a method of administering medications through the skin. This system allows drugs to be absorbed directly into the bloodstream, providing a controlled release over time. Common examples include nicotine patches for smoking cessation and hormone replacement therapy patches. This method can improve patient compliance and reduce gastrointestinal side effects compared to oral medications.

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Research

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research Transdermal delivery of mixnoxidil with block copolymer nanoparticles

253 citations , June 2004 in “Journal of Controlled Release”

The research observed that 40-nm self-assembled nanoparticles enhanced minoxidil penetration in hairy guinea pig skin compared to 130-nm nanoparticles, but this size effect was absent in hairless skin.

research Ethosomes: New Prospects in Transdermal Delivery

222 citations , January 2003 in “Critical Reviews in Therapeutic Drug Carrier Systems”

This review discusses the capabilities of ethosomes as drug delivery carriers and reports improved outcomes in a clinical study with an ethosomal acyclovir formulation.

research Transdermal delivery of mixnoxidil with block copolymer nanoparticles

181 citations , July 2004 in “Journal of controlled release”

In this study, researchers found that in hairy guinea pig skin, minoxidil delivered via 40-nm nanoparticles had higher skin penetration than 130-nm nanoparticles, indicating nanoparticle size affects permeation.

research Liposomal systems as drug delivery vehicles for dermal and transdermal applications

151 citations , July 2011 in “Archives of Dermatological Research”

This review discusses various strategies to enhance drug delivery through the skin barrier, highlighting liposomes as promising carriers for increased dermal concentrations in topical therapies, but reports no new research results.

research Physicochemical properties of pH-sensitive hydrogels based on hydroxyethyl cellulose–hyaluronic acid and for applications as transdermal delivery systems for skin lesions

118 citations , May 2015 in “European journal of pharmaceutics and biopharmaceutics”

This study found that the pH-sensitive hydrogel HECHA13, containing isoliquiritigenin, effectively inhibited the growth of Propionibacterium acnes and showed promise for transdermal delivery in acne treatment.

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community Different Topical Dutasteride Formulations

3 upvotes 3 years ago

The conversation discusses the best vehicle for topical dutasteride, comparing Trichosol, Transcutol, and a gel version. It also mentions using Transcutol with ethanol to enhance transdermal delivery of Bimatoprost.

community My Idea for a possible new hairloss treatment

53 upvotes 6 years ago

Exploring a potential hair loss treatment using the enzyme AKR1C2 to locally reduce DHT levels. Challenges include enzyme delivery through the skin and high production costs, with gene therapy or stem cells suggested as future alternatives.

community Peptides that Stop Hair Loss? | In-depth Literature Review Video

76 upvotes 2 years ago

Peptides like TB500, KPV, GHK-CU, and BPC-157 are overhyped for hair growth with limited proven effectiveness in humans. Combining peptides with delivery methods like iontophoresis and sonophoresis shows promise, but many claims remain unproven.

community Topical fin - why are people still using alcohol carriers when liposomal is proven to be better?

7 upvotes 1 year ago

Liposomal carriers for topical finasteride offer better targeting, reduced side effects, and less irritation compared to alcohol-based solutions, but availability and cost may limit their use. Minoxidil can dissolve in liposomal carriers, enhancing delivery and stability.

community Switching RU vehicle due to scalp irritation – anyone tried low-EtOH + squalane / emu oil?

in Treatment 2 upvotes 9 months ago

The user is experiencing scalp irritation from using RU58841 with a 70% ethanol and 30% propylene glycol vehicle and is considering switching to a less irritating vehicle, such as 30% ethanol with 70% squalane or emu oil. They are seeking feedback on the effectiveness and irritation levels of these alternative carriers.

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