Modulating Metal-Organic Frameworks by Surface Engineering of Stearic Acid Modification for Follicular Drug Delivery and Enhanced Hair Growth Promotion

    February 2025 in “ Journal of Nanobiotechnology
    Zehui He, Zhenda Liu, Yongtai Zhang, Teng Guo, Nianping Feng
    TLDR Modified frameworks with stearic acid enhance drug delivery and promote hair growth.
    The study investigates a novel drug delivery system using stearic acid-modified metal-organic frameworks (SA-MOF) for treating androgenetic alopecia (AGA). This system, loaded with the natural product cardamonin (CAR), enhances drug stability, release, and follicular penetration. In vitro and in vivo experiments, including tests on C57BL/6 mice, showed that CAR@SA-MOF promotes hair growth by transitioning hair follicles to the anagen phase and enhancing cell proliferation and migration. The SA-MOF system also activates key signaling pathways like Wnt/β-catenin, AKT/ERK, and SHH/Gli, and regulates growth factors such as IGF-1 and VEGF, indicating its potential as a promising therapeutic strategy for hair loss with minimal adverse effects.
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