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    Preparation and Characterization of Dutasteride-Loaded Nanostructured Lipid Carriers Coated with Stearic Acid-Chitosan Oligomer for Topical Delivery

    April 2017 in “ European Journal of Pharmaceutics and Biopharmaceutics ”
    Norhayati Mohamed Noor, Khalid Sheikh, Satyanarayana Somavarapu, Kevin Taylor
    Studysummary This study found that dutasteride-loaded nanostructured lipid carriers coated with a stearic acid-chitosan oligomer are stable, less cytotoxic, and suitable for topical delivery to promote hair growth.
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    Research cited in this study 13

    1. Histological Assessment of Follicular Delivery of Flutamide by Solid Lipid Nanoparticles: Potential Tool for the Treatment of Androgenic Alopecia Drug Development and Industrial Pharmacy · 2015
    2. Inverse Micellar Sugar Glass (IMSG) Nanoparticles for Transfollicular Vaccination Journal of controlled release · 2015
    3. Enhanced Skin Permeation of 5α-Reductase Inhibitors Entrapped into Surface-Modified Liquid Crystalline Nanoparticles Archives of Pharmacal Research · 2014
    4. Squarticles as a Lipid Nanocarrier for Delivering Diphencyprone and Minoxidil to Hair Follicles and Human Dermal Papilla Cells Aaps Journal · 2013
    5. The Efficacy and Safety of 5α-Reductase Inhibitors in Androgenetic Alopecia: A Network Meta-Analysis and Benefit–Risk Assessment of Finasteride and Dutasteride Journal of Dermatological Treatment · 2013
    6. Effects of 5-Alpha Reductase Inhibitors on Erectile Function, Sexual Desire, and Ejaculation Expert Opinion on Drug Safety · 2012
    7. Male Pattern Baldness and the Risk of Prostate Cancer Annals of Oncology · 2011
    8. Selective Follicular Targeting by Modification of the Particle Sizes Journal of Controlled Release · 2011
    9. Follicular and Percutaneous Penetration Pathways of Topically Applied Minoxidil Foam European Journal of Pharmaceutics and Biopharmaceutics · 2010
    10. Efficacy, Safety, and Tolerability of Dutasteride 0.5 mg Once Daily in Male Patients with Male Pattern Hair Loss: A Randomized, Double-Blind, Placebo-Controlled, Phase III Study Journal of The American Academy of Dermatology · 2010
    11. In Vitro Skin Permeation of Hinokitiol Loaded in Vesicles Composed of Behenyltrimethylammonium Chloride and Stearic Acid Drug development and industrial pharmacy · 2010
    12. The Importance of Dual 5α-Reductase Inhibition in the Treatment of Male Pattern Hair Loss: Results of a Randomized Placebo-Controlled Study of Dutasteride Versus Finasteride Journal of The American Academy of Dermatology · 2006
    13. Balding Hair Follicle Dermal Papilla Cells Contain Higher Levels of Androgen Receptors Than Those From Non-Balding Scalp Journal of Endocrinology · 1998