Enhanced Therapeutic Effects of All-Trans Retinoic Acid Nanostructured Lipid Carrier Composite Gel Drug Delivery System for Alopecia Areata

    May 2025 in “ Journal of Nanobiotechnology ”
    Lingling Zheng, Yang Du, Lulu Zhang, Feihong Jin, Wangting Li, Xuan Zhou, Yanping Yin, Yan Weng, Dong Xu, Jingwen Wang
    TLDR The gel improves hair regrowth and reduces irritation in alopecia areata treatment.
    The study explores the use of an all-trans retinoic acid-loaded nanostructured lipid carrier gel (ATRA-NLC-Gel) for treating alopecia areata (AA), demonstrating improved therapeutic effects over traditional ATRA cream. The ATRA-NLC-Gel enhances transdermal permeability, targets hair follicles more effectively, reduces skin irritation, and allows for a slow, sustained release of ATRA. In AA model mice, the gel improved symptoms by upregulating CD200 and Ki-67 expression and activating the Wnt/β-catenin pathway, leading to restored follicular immune homeostasis and enhanced hair regrowth. The study concludes that ATRA-NLC-Gel is a promising strategy for AA treatment in clinical settings.
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