Nanocarrier Systems for Transdermal Drug Delivery
October 2012
in “
InTech eBooks
”
nanocarrier systems transdermal drug delivery nanoparticles liposomes dendrimers nanostructures drug solubility drug penetration targeted delivery intercellular lipid route transcellular route follicular penetration drug absorption bioavailability controlled release prednicarbate tretinoin-loaded solid lipid nanoparticles cytotoxicity molecular properties toxicology nanocarriers skin penetration drug uptake drug release skin irritation
TLDR Nanocarriers could improve how drugs are delivered through the skin but require more research to overcome challenges and ensure safety.
The document from 2012 provides a comprehensive overview of nanocarrier systems for transdermal drug delivery, discussing the potential of nanoparticles, liposomes, dendrimers, and other nanostructures to enhance drug solubility, penetration, and targeted delivery while reducing side effects. It details the skin's structure and the pathways for drug penetration, including the intercellular lipid route, transcellular route, and follicular penetration. Nanocarriers are shown to improve drug absorption, bioavailability, and controlled release, with specific examples such as improved uptake of prednicarbate and reduced irritation with tretinoin-loaded solid lipid nanoparticles. However, challenges such as high costs, stability issues, cytotoxicity, and the need for further research on the molecular properties influencing drug penetration and the toxicology of nanostructures are also highlighted. The document concludes that nanocarriers hold promise for enhancing transdermal drug delivery, but more research is needed to fully understand their interactions with biological entities and to optimize their use in pharmaceutical products.
